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Table 3 List of genes potentially specifically involved in neoplastic progression in MMTV-Wnt-1 transgenic mice

From: Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1transgenic mice

    Expression ratio
Image ID Gene name Symbol WntH/V WntT/WntH WntT/NeuT
474107 Tumor necrosis factor receptor superfamily, member 19 Tnfrsf19 2.56 3.48 6.23
406897 Retinol binding protein 1, cellular Rbp1 2.93 3.02 1.96
572428 Cell cycle cyclin D1 Mm.35804 Cyclin D1 Ccnd1 = 5.53 1.97
536306 Hormone/GF growth/diff 1 Mm.22621 Procollagen type I α1 Col1a1 = 3.04 3.27
536526 ESTs   = 8.8 5.95
329780 Cadherin 3 Cdh3 = 3.74 3.96
427360 Mus musculus, clone IMAGE:3590270, mRNA, partial cds LOC192176 = 3.5 2.44
638805 Expressed sequence AI504637   = 3.3 2.27
355990 Chondroitin sulfate proteoglycan 2 Cspg2 = 3.62 5.05
574500 ESTs   = 4.13 1.65
476431 Nerve growth factor receptor Ngfr = 3.61 6.34
680894 Glial cell line derived neurotrophic factor family receptor α1 Gfra1 = 4.74 4.05
482943 Odd-skipped related 1 (Drosophila) Osr1 = 4.1 3.65
695687 Calponin 2 Cnn2 = 3.49 2.54
335572 Dihydropyrimidinase-like 3   = 3.27 7.61
621246 Interferon concensus sequence binding protein Icsbp = 3.38 4.91
482170 Four jointed box 1 (Drosophila) Fjx1 = 4.13 3.78
468019 IL-17b Il17b = 4.27 5.37
373716 Tumor-associated calcium signal transducer 2 Tacstd2 = 4.16 3.69
479405 ESTs   = 3.01 4.95
722262 Wingless-related MMTV integration site 5A Wnt5a = 4.44 9.23
719592 GATA binding protein 2 Gata2 = 6.06 10.54
1247541 Apolipoprotein D Apod = 4.67 3.86
331186 Caveolin, caveolae protein, 22 kDa Cav1 0.31 0.29 3.67
596968 Caveolin, caveolae protein, 22 kDa Cav1 0.3 0.31 3.05
948509 Caveolin, caveolae protein, 22 kDa Cav1 0.52 0.18 3
386555 CD36 antigen Cd36 0.21 0.06 0.08
832585 ESTs   0.21 0.06 0.21
620819 transcription elongation factor A (SII) 1 AI158848 0.24 0.07 0.25
831701 ESTs   0.2 0.09 0.25
775253 ESTs   0.16 0.07 0.22
334182 Unknown   0.24 0.06 0.21
493675 Riken cDNA 2700018N07 gene Scd1 0.18 0.1 0.21
571367 Riken cDNA 2410012F02 gene   0.24 0.11 0.27
463388 Epoxide hydrolase 2, cytoplasmic Ephx2 0.3 0.11 0.41
374030 EST   0.25 0.11 0.33
1067881 Fc receptor, IgG, low affinity III Fcgr3 0.36 0.16 0.26
474184 Expressed sequence AW554339   0.3 0.15 0.33
579349 Expressed sequence AI593221 2410127E18Rik 0.29 0.18 0.23
874232 Riken cDNA 1110025G12 gene 1110025G12Rik 0.33 0.19 0.56
891453 Expressed sequence AI315208 AI315208 = 0.2 0.16
1399595 Riken cDNA 2810422B09 gene 1810061M12Rik 0.3 0.18 0.4
737745 ESTs   0.34 0.17 0.37
876063 BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 Bnip3 0.38 0.27 0.62
850642 Epoxide hydrolase 2, cytoplasmic Ephx2 0.18 0.22 0.44
1248105 Expressed sequence AI595343 AI595343 0.42 0.21 0.37
330661 Mus musculus golli-interacting protein mRNA, complete cds Nif3 0.66 0.21 0.22
1349720 Apoptosis NIP3, Bcl-2-binding protein homolog (Nip3) mRNA Bnip3 0.37 0.29 0.52
1067414 Expressed sequence AI413399 1110001E17Rik = 0.24 0.52
832584 ESTs, Weakly similar to STHM MOUSE STATHMIN [M. musculus]   0.31 0.21 0.46
876369 Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) Als2 0.41 0.29 0.39
764542 ESTs, Weakly similar to GPRY_mouse probable G protein-coupled receptor GPR34 [M. musculus] Gpr43 0.49 0.24 0.43
1248075 Transcription factor 1 Tcf1 0.29 0.31 0.36
949592 ESTs, Moderately similar to hypothetical protein [H. sapiens]   = 0.32 0.22
1195295 Actinin α3 Actn3 = 0.29 0.43
820307 A kinase (PRKA) anchor protein (gravin) 12 Akap12 = 0.31 0.08
864409 Riken cDNA 1200013I08 gene 1200013I08Rik 0.47 0.33 0.39
947659 Riken cDNA 2310016E22 gene 2310016E22Rik = 0.33 0.37
1396547 Myosin binding protein H   = 0.25 0.45
  1. This list displays genes that are differentially expressed between mammary tumors (WntT) and hyperplastic mammary gland (WntH) from MMTV-Wnt-1 transgenic mice, and that are also differentially expressed between WntT and mammary tumors from MMTV-Neu transgenic mice (NeuT). Genes are sorted according to the average ratio of WntT versus WntH. A numeric ratio is displayed if the gene expression meets the criteria (statistical significance and fold cutoff) described in Table 2; otherwise, it is marked as '=', indicating that there is no significant difference between the two sets of samples in comparison. EST, expressed sequence tag; MMTV, mouse mammary tumor virus.