Predicted transcriptional regulators. Rosetta predictions for three Halobacterium NRC-1 proteins that are consistent with transcription regulation and/or DNA binding. (a) The top ranked Rosetta structure prediction for VNG0462C (according to the Rosetta confidence function) is shown next to the diphtheria toxin repressor (1bi2-B). The predicted operon for VNG0462 is shown below; red/pink boxes above the line in this diagram are genes on the 3' strand while genes indicated by rectangles below the line are genes on the 5' strand. (b) The top ranked model for VNG5156H (left) is shown next to 1bi2-B, the predicted operon containing VNG5156, VNG5154, VNG5153 and VNG5152 is shown below. (c) The top ranked Rosetta prediction for VNG0039H is shown next to its closest match in the PDB, 1bi2-B.