Figure 2

Chemotaxis methyl accepting domains. (a) Htr10 (VNG1505g) domain 1 hit to 1ljwA, hemoglobin. The recently deposited structure for the Hemat Sensor domain (1OR4-A) is also shown (red box). The position of the heme (black spheres) is similar in both our predicted fold match (1LJW-A) and the match detected by PSI-BLAST (1OR4-A) (b) Htr13 (VNG1013g) hit to Gga1 (1jwfA, involved in protein transport, binding of dipeptide signal sequence), (c) the association network surrounding CheA and its interactions with the Htr methyl accepting domains found in the Halobacterium genome, as predicted by the phylogenetic profile method (red lines). Also shown are predicted operon edges (black lines). The expression levels (where red corresponds to a high level of expression and green to a low expression relative to a reference; white indicates no change/no measurement) are from a previously described microarray experiment. Nodes marked with asterisks indicate proteins where a domain was folded with Rosetta (resulting in a significant fold match) or annotated using fold recognition. Nodes marked with a 'P' are proteins that were annotated using Pfam. The '!' by yufN indicates that the prior annotation does not agree with our current analysis.