Table 3 Conservation index differences by disease system for model organisms
From: Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes
Disease system | Mouse | Rat | Fish | Fly | Nematode | Yeast |
|---|---|---|---|---|---|---|
IDE | -0.46 | -0.49 | -0.91 | 0.04 | -0.52 | -0.42 |
Bone_connectivetissue | 1.14 | 0.04 | -0.85 | -1.70 | -2.42 | -0.26 |
Cancer | -1.01 | -1.42 | -1.26 | -0.85 | -0.56 | -0.01 |
Cardiovascular | 0.90 | -0.15 | -1.33 | -1.70 | -0.72 | -1.74 |
Endocrine | -0.96 | -0.30 | 0.19 | -1.34 | -1.81 | -2.26 |
Hematological | -5.05 | -4.96 | -0.68 | -0.59 | -0.21 | 0.59 |
Hepatic_GI_pancreatic | -2.41 | -2.67 | -0.07 | -1.01 | -1.05 | -1.36 |
Immune | -6.93 | -5.52 | -5.81 | -3.42 | -1.52 | 0.05 |
Malformationsyndrome | 4.17 | 3.06 | 0.09 | -2.88 | -3.67 | -2.55 |
Metabolic | 2.46 | 2.88 | 4.34 | 5.64 | 7.43 | 2.18 |
Muscle | 3.24 | 2.24 | 0.87 | -1.17 | -0.66 | 1.42 |
Neurological | 4.95 | 4.91 | 1.93 | 1.24 | -0.30 | 0.55 |
Nonneuraleye | 0.46 | 0.43 | 0.04 | 0.58 | -1.00 | -0.07 |
Other | -0.87 | -0.46 | -1.46 | -0.13 | 0.62 | 2.03 |
Pulmonary | -3.67 | -3.77 | -0.34 | -0.46 | -3.03 | -1.18 |
Renal | -1.64 | -1.26 | -0.01 | 0.61 | 0.01 | -0.52 |
Skin | -1.52 | -0.86 | -0.25 | -0.17 | -0.09 | 0.04 |