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Table 3 Conservation index differences by disease system for model organisms

From: Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes

Disease system Mouse Rat Fish Fly Nematode Yeast
IDE -0.46 -0.49 -0.91 0.04 -0.52 -0.42
Bone_connectivetissue 1.14 0.04 -0.85 -1.70 -2.42 -0.26
Cancer -1.01 -1.42 -1.26 -0.85 -0.56 -0.01
Cardiovascular 0.90 -0.15 -1.33 -1.70 -0.72 -1.74
Endocrine -0.96 -0.30 0.19 -1.34 -1.81 -2.26
Hematological -5.05 -4.96 -0.68 -0.59 -0.21 0.59
Hepatic_GI_pancreatic -2.41 -2.67 -0.07 -1.01 -1.05 -1.36
Immune -6.93 -5.52 -5.81 -3.42 -1.52 0.05
Malformationsyndrome 4.17 3.06 0.09 -2.88 -3.67 -2.55
Metabolic 2.46 2.88 4.34 5.64 7.43 2.18
Muscle 3.24 2.24 0.87 -1.17 -0.66 1.42
Neurological 4.95 4.91 1.93 1.24 -0.30 0.55
Nonneuraleye 0.46 0.43 0.04 0.58 -1.00 -0.07
Other -0.87 -0.46 -1.46 -0.13 0.62 2.03
Pulmonary -3.67 -3.77 -0.34 -0.46 -3.03 -1.18
Renal -1.64 -1.26 -0.01 0.61 0.01 -0.52
Skin -1.52 -0.86 -0.25 -0.17 -0.09 0.04
  1. Standardized scores from multi-level Wilcoxon analyses are shown. Categories that contribute to the global differences among systems with a sample size greater than 2% of the total are shown in bold, and were also used to generate Figure 6.