Figure 1
From: Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes
KA/KS, KS, and KA distributions of ortholog pairs for disease versus non-disease genes. (a) The KA/KS ratio, (b) KS, the number of synonymous substitutions per synonymous site, and (c) KA, the number of non-synonymous substitutions per non-synonymous sites, were calculated for 1:1 human:rat orthologs for a set containing human genes associated with disease and a set containing human genes not known to be associated with disease.