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Table 2 ESTs from adult cDNAs with known homologs, classified by function

From: Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensisand the evolution of secreted proteins in parasites

Cluster number Conventional cDNAs Oligo-capped cDNAs P Accession Description
Proteases/proteosome/ubiquitin
NBC00018 2 0 1e-33 S66528 26S proteinase regulatory complex, non-ATPase chain (Drosophila melanogaster)
NBC00030 2 0 8e-56 U41556 Cysteine protease CPR-6 (Caenorhabditis elegans)
NBC00086 1 0 3e-29 A48454 Cathepsin B-like cysteine proteinase (Ostertagia ostertagi)
    5e-28 D48435 Cysteine proteinase AC-3 (Haemonchus contortus)
NBC00168 1 0 2e-42 NM_065563 Calpain thiol protease (Caenorhabditis elegans)
NBC00198 1 0 7e-60 NM_073736 Cysteine protease (legumain, asparaginyl endopeptidase) (Caenorhabditis elegans)
NBC00204 3 0 2e-32 NM_072733 Protease (aspartic) (Caenorhabditis elegans)
NBC00231 2 0 5e-90 NM_064106 Serine carboxypeptidase (Caenorhabditis elegans)
NBC00307 1 0 2e-32 NM_015277 Ubiquitin-protein ligase NEDD4-like; neural precursor (Homo sapiens)
NBC00311 1 0 5e-31 NM_073736 Cysteine protease (legumain, asparaginyl endopeptidase) (Caenorhabditis elegans)
NBC00352 2 0 6e-31 NM_065253 Ubiquitin (Caenorhabditis elegans)
NBC00348 1 0 2e-83 A48145 Ubiquitin-conjugating enzyme, UBC-2 (Caenorhabditis elegans)
NBC00362 1 0 1e-76 S17521 Multicatalytic endopeptidase complex (proteasome) zeta chain (Caenorhabditis elegans)
NBC00368 1 0 9e-13 LCE_ORYLA Low choriolytic enzyme precursor (zinc metalloprotease) (Oryzias latipes)
NBC00377 1 0 3e-75 PSA4_CAEEL Proteasome subunit, alpha type 4, PAS-3 (Caenorhabditis elegans)
NBC00459 2 1 2e-26 NM_072733 Protease (aspartic) (Caenorhabditis elegans)
NBC00469 1 0 7e-17 NM_060215 Zinc metalloprotease (Caenorhabditis elegans)
NBC00509 1 1 4e-71 AL161503 Polyubiquitin, UBQ10 (Arabidopsis thaliana)
NBC00664 0 1 5e-09 NM_074798 Cathepsin-like (cysteine) protease (Caenorhabditis elegans)
NBC00670 0 1 3e-18 S17435 Polyubiquitin 6 (Helianthus annuus)
NBC00772 0 1 4e-24 NM_003352 Sentrin, ubiquitin-like small protein (Gallus gallus)
NBC00783 0 1 2e-89 U41556 Cysteine protease CPR-6 (Caenorhabditis elegans)
NBC00828 0 1 9e-63 NC_003424 Pad1 protein; 26S proteasome subunit (Schizosaccharomyces pombe)
Enzymes (other than proteases)
NBC00045 2 0 2e-92 NM_065870 Fructose-biphosphate aldolase (Caenorhabditis elegans)
NBC00049 1 0 9e-50 NM_070783 Lipase (Caenorhabditis elegans)
NBC00066 2 1 7e-76 NM_074348 Peptidyl-prolyl cis-trans isomerase (Caenorhabditis elegans)
NBC00079 1 0 2e-35 NM_058712 Helicase (Caenorhabditis elegans)
NBC00102 1 0 7e-37 NM_074031 Peroxidase-like (Caenorhabditis elegans)
NBC00139 1 0 8e-29 NM_060074 Hexokinase (Caenorhabditis elegans)
NBC00143 1 0 4e-66 ADHX_MYXGL Alcohol dehydrogenase class III (Caenorhabditis elegans)
NBC00147 1 0 6e-19 XM_087230 Similar to Uridine phosphorylase (UDRPase) (Homo sapiens)
NBC00157 1 0 3e-13 XM_058660 Similar to Protein tyrosine phosphatase 1E (Homo sapiens)
NBC00173 1 0 5e-72 AJ440747 Protein disulphide isomerase 1 (Ostertagia ostertagi)
NBC00183 1 0 3e-56 T46280 Isocitrate dehydrogenase, NADP+, cytosolic (Homo sapiens)
NBC00189 1 0 1e-21 XM_129069 Similar to Acetyltransferase (GNAT) family (Mus musculus)
NBC00212 1 0 6e-57 NM_016100 N-terminal acetyltransferase complex ard1 subunit (Homo sapiens)
NBC00283 1 0 4e-27 NM_012088 6-phosphogluconolactonase (Homo sapiens)
NBC00285 1 0 2e-47 LDHA_ANGRO L-lactate dehydrogenase A chain (Anguilla rostrata)
NBC00290 1 0 3e-17 I55976 Dihydrolipoamide S-acetyltransferase (Rattus norvegicus)
NBC00292 1 0 1e-40 NM_006223 Peptidyl-prolyl cis/trans isomerase (Homo sapiens)
NBC00304 1 0 4e-12 NM_073341 Glucose-1-dehydrogenase (Caenorhabditis elegans)
NBC00309 1 0 1e-18 NM_066225 Hydroxymethylglutaryl-coA reductase (Caenorhabditis elegans)
NBC00326 1 0 1e-65 NM_065761 Protein phosphatase 2A (Caenorhabditis elegans)
NBC00337 1 0 2e-60 GMD1_CAEEL Probable GDP-mannose 4,6 dehydratase 1 (Caenorhabditis elegans)
NBC00353 1 0 2e-56 NM_065537 ATP synthase B chain (Caenorhabditis elegans)
NBC00378 1 0 2e-43 NM_073253 Acetyltransferase (GNAT) family (Caenorhabditis elegans)
NBC00382 1 0 4e-49 NM_063827 Phospholipase A2 (Caenorhabditis elegans)
NBC00389 2 0 1e-48 NM_058626 Phosphotransferase (Caenorhabditis elegans)
NBC00404 1 0 2e-76 NM_064078 Glucosamine-fructose-6-phosphate aminotransferase (Caenorhabditis elegans)
NBC00413 1 0 6e-22 NM_078324 AMP-activated protein kinase (Caenorhabditis elegans)
NBC00427 1 0 2e-20 NC_003423 3-oxoacyl-(acyl-carrier-protein)-synthase (Schizosaccharomyces pombe)
NBC00475 1 0 3e-42 NM_065313 Serine/threonine protein phosphatase (Caenorhabditis elegans)
NBC00483 1 0 4e-25 NM_059984 Phospholipase, similar to ADRAB-b (Caenorhabditis elegans)
NBC00504 1 0 7e-65 AF292096 Protein kinase AIRK2 (Xenopus laevis)
NBC00508 1 2 5e-64 PPCK_HAECO Phosphoenolpyruvate carboxykinase (Haemonchus contortus)
NBC00528 1 0 5e-66 PPCK_HAECO Phosphoenolpyruvate carboxykinase (Haemonchus contortus)
NBC00561 0 7 1e-54 NDKB_RAT Nucleoside diphosphate kinase B (Rattus norvegicus)
NBC00713 0 1 1e-08 XM_140038 Similar to tau-tubulin kinase (Mus musculus)
NBC00729 0 2 4e-21 NM_079041 Flap endonuclease 1 (Drosophila melanogaster)
NBC00743 0 1 3e-64 G3P_BRUMA Glyceraldehyde 3-phosphate dehydrogenase (Brugia malayi)
NBC00745 0 1 4e-13 NM_068436 Casein kinase (Caenorhabditis elegans)
NBC00689 0 3 2e-17 CLYC_CAEEL Serine hydroxymethyltransferase MEL-32 (Caenorhabditis elegans)
NBC00696 0 2 2e-15 NM_000414 Hydroxysteroid (17-beta) dehydrogenase 4 (Homo sapiens)
NBC00770 0 1 3e-45 NM_066907 Serine/threonine kinase, casein kinase-like (Caenorhabditis elegans)
NBC00777 0 1 8e-21 OAZ_PRIPA Ornithine decarboxylase antizyme (Pristionchus pacificus)
NBC00796 0 1 8e-52 XM_125017) Putative lysophosphatidic acid acyltransferase (Mus musculus)
NBC00802 0 1 4e-49 NM_078623 Enoyl Coenzyme A hydratase, short chain 1 (Rattus norvegicus)
Structural
NBC00056 1 0 4e-58 NM_071024 Actin depolymerizing factor (Caenorhabditis elegans)
NBC00062 1 0 1e-11 NM_006400 Dynactin 2; dynactin complex 50 kD subunit; dynamitin (Homo sapiens)
NBC00078 2 0 0 NM_059538 Calponin (Caenorhabditis elegans)
NBC00097 1 0 1e-42 MLR1_CAEEL Myosin regulatory light chain 1 (Caenorhabditis elegans)
NBC00142 1 0 2e-76 S53776 Beta-tubulin isotype I (Haemonchus contortus)
NBC00172 2 0 0 NM_073416 Actin (Caenorhabditis elegans)
NBC00224 1 0 2e-40 NM_063850 Troponin C (Caenorhabditis elegans)
NBC00239 4 1 2e-39 NM_077559 Collagen (Caenorhabditis elegans)
NBC00241 2 0 2e-47 NM_069715 Collagen (Caenorhabditis elegans)
    6e-47 NM_077291 Cuticular collagen (Caenorhabditis elegans)
NBC00246 1 1 3e-19 NM_077087 Troponin I (Caenorhabditis elegans)
NBC00287 2 0 2e-61 MLR1_CAEEL Myosin regulatory light chain 1 (Caenorhabditis elegans)
NBC00360 1 1 3e-30 NM_145671 Actinfilin (Rattus norvegicus)
NBC00396 1 0 2e-67 MYSP_CAEEL Paramyosin (Caenorhabditis elegans)
NBC00403 1 0 3e-32 NM_077291 Cuticular collagen (Caenorhabditis elegans)
NBC00418 1 0 6e-27 NM058881 Calponin (Caenorhabditis elegans)
NBC00430 1 0 3e-11 NM_011722 Dynactin 6; p27 dynactin subunit (Mus musculus)
NBC00526 1 0 2e-44 NM_060857 Profilin (Caenorhabditis elegans)
NBC00552 0 1 9e-47 MYSP_CAEEL Paramyosin (Caenorhabditis elegans)
NBC00569 0 1 1e-23 NM_060369 Alpha crystallin B chain (Caenorhabditis elegans)
NBC00749 0 1 3e-43 NM_060857 Profilin (Caenorhabditis elegans)
Embryo/egg/mating etc
NBC00068 3 0 1e-25 VIT5_CAEEL Vitellogenin 5 precursor (Caenorhabditis elegans)
NBC00161 1 0 2e-15 VIT5_CAEEL Vitellogenin 5 precursor (Caenorhabditis elegans)
NBC00397 1 9 7e-61 MS10_CAEEL Major Sperm Protein 10 (Caenorhabditis elegans)
NBC00523 1 0 4e-69 XM_038960 Similar to preimplantation protein 3 (Homo sapiens)
NBC00585 0 5 2e-30 NM_076467 Vitellogenin (Caenorhabditis elegans)
NBC00611 0 1 1e-25 NM_060189 Placental protein 11 (Caenorhabditis elegans)
Transporters/receptors/lectins and other binding proteins
NBC00027 2 0 9e-17 NM_062882 Lectin, C-type (Caenorhabditis elegans)
    5e-15 NM_076712 Asialoglycoprotein receptor (C-type lectin) (Caenorhabditis elegans)
NBC00110 1 0 4e-17 NC_001263 Acyl-CoA-binding protein (Deinococcus radiodurans)
NBC00118 1 0 4e-41 T31073 Multidrug resistance P-glycoprotein (Haemonchus contortus)
NBC00128 3 0 1e-92 NM_067381 ADP/ATP carrier protein/translocase (Caenorhabditis elegans)
NBC00167 1 0 2e-12 NM_130415 Lysosomal amino acid transporter 1 (Rattus norvegicus)
NBC00175 1 0 7e-15 A48925 Mannose receptor (C-type lectin), macrophage (Mus musculus)
NBC00319 1 0 8e-15 NXT2_HUMAN NTF2-related export protein 2 (p15-2 protein) (Homo sapiens)
NBC00324 2 0 7e-15 AJ243873 Galectin (S-type lectin) (Haemonchus contortus)
NBC00340 1 0 2e-61 NM_077246 Galectin (S-type lectin) LEC-10 (Caenorhabditis elegans)
NBC00355 1 0 8e-21 NM_059527 Fatty acid-binding protein LBP-6 (Caenorhabditis elegans)
NBC00363 1 0 6e-48 NM_016208 Vacuolar protein sorting 28 homolog (Homo sapiens)
NBC00583 0 5 4e-35 NM_065836 Low density lipoprotein receptor (Caenorhabditis elegans)
NBC00593 0 2 2e-26 NM_059525 Fatty acid-binding protein LBP-6 (Caenorhabditis elegans)
NBC00752 0 1 3e-08 NM_059071 Acetylcholine receptor UNV-38 (Caenorhabditis elegans)
NBC00766 0 1 7e-44 POR2_MELGA Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Meleagris gallopavo)
NBC00808 0 1 6e-53 NM_072174 Calreticulin precursor (Caenorhabditis elegans)
NBC00838 0 1 1e-78 NM_063349 T-complex protein, delta subunit (cytosolic chaperonin CCT-4) (Caenorhabditis elegans)
Signaling
NBC00207 1 0 0 RAB2_LYMST RAS-Related protein RAB-2 (Lymnea stagnalis)
NBC00252 1 0 8e-97 NM_070558 RAS-like GTP-binding protein RhoA (Caenorhabditis elegans)
NBC00297 1 0 4e-17 NM_009106 Rhotekin (Mus musculus)
NBC00312 1 0 4e-46 A35350 Protein kinase C inhibitor (Bos bovis)
NBC00269 1 0 1e-43 NM_058274 RAS-related protein RAB-11 (Caenorhabditis elegans)
NBC00282 1 0 9e-25 NP_741191 A kinase anchor protein 1 (Caenorhabditis elegans)
NBC00395 1 0 2e-29 NM_07328 RAS-like GTP-binding protein (cdc42-like) (Caenorhabditis elegans)
NBC00436 1 0 2e-44 NM_070985 Calmodulin (Caenorhabditis elegans)
NBC00462 1 0 2e-13 SSRP_DROME Single-strand recognition protein (SSRP) (Chorion-factor 5) (Drosophila melanogaster)
NBC00409 1 0 1e-16 NM_019746 Programmed cell death 5/TFAR19 protein (Mus musculus)
NBC00440 1 0 3e-72 S43599 SNF5 homolog R07E5.3 (Caenorhabditis elegans)
NBC00510 1 0 2e-28 XM_129572 Calcyclin (S100 family) binding protein (Mus musculus)
NBC00629 0 1 1e-20 NM_026297 RAB (RAS oncogene family-like 3) (Mus musculus)
NBC00648 0 1 3e-20 NM_002624 Prefoldin 5 isoform alpha; myc modulator-1; c-myc binding protein (Homo sapiens)
NBC00727 0 1 3e-17 AB091687 TGF-beta induced apotosis protein 3 (Mus musculus)
NBC00768 0 1 3e-18 NM_078471 TGF-beta-1 induced anti-apoptotic factor 1 isoform 1 (Homo sapiens)
NBC00829 0 1 1e-42 A49146 Developmental regulator WNT-4 (Xenopus laevis)
NBC00841 0 1 1e-31 NM_012453 Transducin (beta)-like 2, isoform 1 (Homo sapiens)
DNA-related/transcription/DNA binding/regulation
NBC00024 1 0 1e-37 NM_003752 Eukaryotic translation initiation factor 3, subunit 8 (Homo sapiens)
NBC00048 1 0 1e-28 NM_069150 Glycine-rich RNA-binding protein (Caenorhabditis elegans)
    5e-21 NM_007007 Cleavage and polyadenylation specific factor 6 (Homo sapiens)
NBC00050 1 0 2e-12 HEXP_LEIMA DNA-binding protein HEXBP (Hexamer-binding protein) (Leishmania major)
NBC00055 1 1 2e-24 NM_060622 RNA recognition motif (RRM, RBD, or RNP domain) (Caenorhabditis elegans)
NBC00090 2 1 0 NM_066119 Elongation factor 1-alpha (Caenorhabditis elegans)
NBC00099 1 0 2e-30 NM_067248 Splicing factor (Caenorhabditis elegans)
NBC00170 1 0 2e-56 NM_011304 RuvB DNA helicase -like protein 2 (Mus musculus)
NBC00181 1 0 4e-13 NM_001698 AU RNA-binding protein/enoyl-Coenzyme A hydratase (Homo sapiens)
NBC00192 1 0 2e-26 NM_060622 RNA recognition motif (RRM, RBD, or RNP domain) (Caenorhabditis elegans)
NBC00210 1 0 3e-15 NM_018403 Transcription factor (SMIF gene) (Homo sapiens)
NBC00267 1 0 4e-20 T2EB_XENLA Transcription initiation factor IIE, beta subunit (Xenopus laevis)
NBC00321 1 0 1e-16 NM_033224 Purine-rich element binding protein B (Homo sapiens)
NBC00280 1 0 3e-58 NM_006578 Guanine nucleotide-binding protein, beta-5 subunit (Homo sapiens)
NBC00350 1 0 6e-40 DPOD_DROME DNA polymerase delta catalytic subunit (Drosophila melanogaster)
NBC00366 2 0 6e-79 NM_066119 Elongation factor 1-alpha (Caenorhabditis elegans)
NBC00370 1 0 1e-17 NM_031992 Eukaryotic translation initiation factor 4H, isoform 2 (Homo sapiens)
NBC00374 1 2 2e-53 NM_070415 Elongation factor 1-beta/delta chain (Caenorhabditis elegans)
NBC00480 1 0 3e-21 NM_061014 Regulator of chromosome condensation, RCC1 (Caenorhabditis elegans)
NBC00543 0 2 5e-23 NM_065536 Zinc finger, C3HC4 type (RING finger) (Caenorhabditis elegans)
NBC00577 0 7 2e-31 NP_872244 Translation elongation factor EFT-4 (Caenorhabditis elegans)
NBC00600 0 1 3e-74 NM_063406 Initiation factor 5A (Caenorhabditis elegans)
NBC00630 0 1 9e-39 SFR4_MOUSE Splicing factor, arginine/serine-rich 4 (Mus musculus)
NBC00764 0 1 4e-16 XM_132357 Similar to Translation Initiation factor EIF-2B alpha (Mus musculus)
NBC00776 0 1 6e-27 SN2L_CAEEL Potential global transcription activator SNF2L (Caenorhabditis elegans)
NBC00791 0 1 5e-38 NM_001207 Basic transcription factor 3 (Homo sapiens)
NBC00816 0 1 2e-24 S3B2_HUMAN Splicing factor 3B subunit 2 (Spliceosome associated protein 145) (Homo sapiens)
Other homologs of interest
NBC00025 1 0 3e-16 AF352714 HC40 putative secretory protein precursor (ASP homolog) (Haemonchus contortus)
NBC00065 1 0 6e-20 AA063577 Secreted protein 5 precursor (ASP homolog) (Ancylostoma caninum)
NBC00095 1 0 8e-59 GLB2_NIPBR Myoglobin (body wall isoform globin) (Nippostrongylus brasiliensis)
NBC00103 1 0 9e-12 DIM1_CAEEL Protein dim-1 (2D-page protein spot 8) (Caenorhabditis elegans)
NBC00029 1 0 5e-17 NM_001545 Immature colon carcinoma transcript 1 (Homo sapiens)
NBC00141 1 0 2e-35 NM_018984 Slingshot 1 (Homo sapiens)
NBC00160 1 0 5e-12 NM_053810 Synaptosomal-associated protein, 29kD (Rattus norvegicus)
NBC00199 1 0 9e-39 AF278538 Nucleosome assembly protein 1 (Xenopus laevis)
NBC00256 2 0 2e-09 NM_075227 Transthyretin-like family (Caenorhabditis elegans)
NBC00293 1 0 7e-08 NC_003424 F-box protein (Schizosaccharomyces pombe)
NBC00399 1 0 2e-22 NM_076443 Calumenin, calcium-binding protein (Caenorhabditis elegans)
NBC00429 1 0 4e-14 XM_122362 Chromobox homolog 2 (Drosophila Pc class) (Mus musculus)
NBC00491 1 0 3e-21 NM_076885 Thrombospondin (Caenorhabditis elegans)
NBC00518 1 0 3e-73 T37461 Mago nashi-like protein (Caenorhabditis elegans)
NBC00544 0 1 2e-45 NM_061213 Alpha-2-macroglobulin family (Caenorhabditis elegans)
NBC00560 0 1 1e-35 NM_021305 SEC61, alpha subunit 2 (Saccharomyces cerevisiae)
NBC00705 0 1 3e-31 DVA1_DICVI DVA-1 nematode polyprotein allergen precursor (NPA) (Dictyocaulus viviparus)
    2e-12 ABA1_ASCSU ABA-1 nematode polyprotein allergen precursor (Body fluid allergen-1) (Ascaris suum)
NBC00753 0 1 4e-10 AF089728 Ancylostoma-secreted protein 2 precursor, ASP-2 (Ancylostoma caninum)
NBC00755 0 1 2e-40 TCPB_CAEEL T-complex protein 1, beta subunit (CCT-beta) (Caenorhabditis elegans)
NBC00757 0 1 2e-68 1432_SCHMA 14-3-3 Protein homolog 2 (14-3-3-2) (Schistosoma mansoni)
NBC00803 0 1 3e-09 ASP_ANCCA Ancylostoma secreted protein (ASP-1) precursor (Ancylostoma caninum)
    3e-09 AF079521 Ancylostoma-secreted protein 1 precursor (ASP-1 homolog) (Necator americanus)
NBC00827 0 1 3e-14 NM_070108 Testis-specific protein TPX-1 like (ASP homolog) (Caenorhabditis elegans)
  1. The table gives, for each numbered cluster, the highest homolog with a functional description where available; in a number of cases a C. elegans homolog exists with a higher similarity, but has no description. Similarities to entries described as 'hypothetical proteins' are excluded, as are heat-shock proteins, cytochromes, mitochondrial and ribosomal products. Where C. elegans protein description is ambiguous (for example, protease, lectin), further descriptors added manually are italicized. Different clusters may derive from a single gene if sequences are non-overlapping; for example, NBC00198 and NBC00311 align to different segments of the C. elegans protease gene NM_073736. This table does not include N. brasiliensis gene products discovered previously and/or reported by other laboratories. All entries for this species are aggregated on the NEMBASE website.