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Table 2 Genes showing significant changes in expression throughout all biological systems tested

From: Orthologous gene-expression profiling in multi-species models: search for candidate genes

Gene symbol Fold change p value ventilation vs control PubMatrix terms
    Lung Lung injury Mechanical ventilation Endothelium Pulmonary endothelium
ALI related        
IL-1B* 1.53 0.023 1536 287 3 1759 70
IL-6 1.84 0.015 963 173 75 527 30
F3 1.52 0.017 411 54 4 713 18
PAI-1* 1.47 0.003 201 31 3 7367 22
COX2* 1.79 0.011 257 28 1 206 9
IL-13 1.30 0.013 327 21 0 62 2
AQP-1 -1.30 0.038 49 9 0 35 6
PLAUR* 1.47 0.033 83 8 0 113 5
FGA* 1.30 0.024 22 4 10 189 12
C/EBP 1.40 0.013 27 3 0 9 2
CCL2 2.00 0.024 11 1 0 9 2
ADMR -1.35 0.022 19 1 0 16 2
VALI candidates        
CXCR4 1.62 0.007 26 0 0 79 4
GJA-1 1.33 0.026 7 0 0 30 1
IL1R2* 1.88 0.026 11 0 0 7 0
GADD45A 1.71 0.004 21 0 0 4 0
BTG-1* 1.38 0.007 2 0 0 1 0
TFF-2* -1.32 0.045 9 0 0 1 0
  1. ADMR, adrenomedullin receptor; AQP-1, aquaporin 1; BTG-1, B-cell translocation gene 1; CCL2, cell chemokine 2; C/EBP, CCAAT/enhancer-binding protein; COX2, prostaglandin G/H synthase and cyclooxygenase 2; CXCR4, chemokine (C-X-C motif) receptor 4; F3, coagulation factor III (thromboplastin, tissue factor); FGA, fibrinogen alpha; GADD45A, growth arrest and DNA-damage-inducible, alpha; GJA-1, gap junction protein, alpha 1 (connexin 43); IL-1B, interleukin 1 beta; IL1R2, interleukin 1 receptor, type II; IL-6, interleukin 6; IL-13, interleukin 13; PAI-1 - plasminogen activator inhibitor type 1; PLAUR, plasminogen activator, urokinase receptor; TFF-2, trefoil factor 2 (spasmolytic protein 1). *Not detected by common single-experiment analysis.