Figure 2
From: Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
A phylogenetic tree of core deaminase sequences. Protein sequences that are predicted from genomic sequences rather than from full cDNA sequences are indicated by asterisks. The vertebrate genes listed include one from the crab-eating monkey Macacus fascicularis. The fish genomes examined are from the zebrafish Danio rerio and pufferfish, Takifugu rubripes and Tetraodon fluviatilis. Two tunicate genomes have been examined, from Ciona intestinalis and Ciona savigni. One squid (Loligo pealeii) is included (J. Rosenthal, personal communication). The insect genomes are of the two Drosophila species, Drosophila melanogaster and Drosophila pseudoobscura, and the malaria mosquito Anopheles gambiae. Alignments were made using T-COFFEE, the boundaries of the core deaminase domain were specified and a tree based on the alignment was generated using MEGA. Bootstrap values are given on all branches.