Table 1 Summary of the recent microarray studies of Kaposi's sarcoma (KS)
From: Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis
Study | Cells used | Time analyzed (post-infection) | Access to database | Major findings |
|---|---|---|---|---|
Wang et al. [1] | Primary LECs and BECs | 2 and 7 days | ArrayExpress [29] Accession number: E-MEXP-66 | Expression profile of KS lesions closly resembles that of endothelial cells; infection of BECs and LECs results in an intermediate gene-expression profile |
Glaunsinger and Ganem [2] | TIME cells (induced lytic replication 2 h post-KSHV infection) | 6, 12 and 20 h | Gene Expression Omnibus [30] Accession number: GSE1406 | Widespread shutoff of host genes during KSHV lytic replication; a subset of genes resistant to shutoff are upregulated during lytic reactivation |
Naranatt et al. [5] | Primary DMVECs | 2 and 4 h | Contact Dr Bala Chandran (University of Kansas Medical Center, Kansas City USA) | 215 genes upregulated; 109 genes downregulated |
Poole et al. [3] | Primary DMVECs | 3 and 5 weeks | Pevsner lab website [31] | Around 2% of genes upregulated and 2% downregulated |
Moses et al. [4] | DMVECs previously immortalized with HPV proteins E6 and E7 | 4 weeks | Früh lab website [32] | 124 genes upregulated; 60 genes downregulated |