Table 1 Cross-talk between cellular processes after PRODISTIN classification

Superimposed cellular processes

PRODISTIN classes composed of doubly annotated proteins

Cell stress other metabolism

10

Cell structure protein folding

14

Lipid fatty acid metabolism protein translocation

23

PolII transcription protein degradation

34

RNA processing and modification RNA splicing

50

Partially overlapping cellular processes

PRODISTIN classes composed of at least three proteins annotated for a cellular role, three proteins annotated for another one, with some doubly annotated

Cell polarity cell structure

7

Cell polarity mating response

9

Cell Structure protein complex assembly

13

Chromosome and chromatin structure mitosis

17

Mating response differentiation

24

Protein degradation vesicular transport

45

Nested cellular processes

Nested PRODISTIN classes

Aging ⊂ Signal transduction

0 ⊂ 54

Cell cycle control ⊂ Amino acid metabolism

3 ⊂ 1

Cytokinesis ⊂ Cell polarity

20 ⊂ 8, 21 ⊂ 8

Mating response ⊂ Cell polarity

25 ⊂ 8, 26 ⊂ 8

Cell polarity/Mating response ⊂ Signal transduction

9 ⊂ 54

Cell stress ⊂ Protein degradation/Vesicular transport

11 ⊂ 45

Cell stress ⊂ Signal transduction

12 ⊂ 54

Cell structure/Protein complex assembly ⊂ Mitosis

13 ⊂ 28

Chromatin/Chromosome structure ⊂ PolII transcription

16 ⊂ 35

Mating response/Differentiation ⊂ Signal transduction

24 ⊂ 54

PolIII transcription ⊂ PolII transcription

42 ⊂ 39

RNA processing and modification ⊂ Nucleus-cytoplasm transport

51 ⊂ 31

RNA splicing ⊂ RNA processing/modification

53 ⊂ 52

Vesicular transport ⊂ Cell polarity/cell structure

55 ⊂ 7

Vesicular transport ⊂ Cell polarity

59 ⊂ 8

Unknown ⊂ Cell structure/protein folding

60 ⊂ 14

Unknown ⊂ Vesicular transport

62 ⊂ 56