Articles selected by Faculty of 1000: yeast metabolomics; genome-wide threading-based predictions; dissecting C. albicans growth pathways; knockout rats; ENU mutagenesis and humoral immunity

Summary

A selection of evaluations from Faculty of 1000 covering yeast metabolomics, genome-wide threading-based predictions of protein-protein interactions, genetic analysis of filamentous growth in C. albicans, the production of knockout rats and genome-wide mutagenesis of humoral immune responses.

Yeast metabolomics

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Allen J, Davey HM, Broadhurst D, Heald JK, Rowland JJ, Oliver SG, Kell DB. Nat Biotechnol 2003, 21:692-696.

For the Faculty of 1000 evaluation of this article please see: http://genomebiology.com/reports/F1000/gb-2003-4-8-333.asp#Allen

Genome-wide threading-based predictions

Multimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome. Lu L, Arakaki AK, Lu H, Skolnick J. Genome Res 2003, 13:1146-1154.

For the Faculty of 1000 evaluation of this article please see: http://genomebiology.com/reports/F1000/gb-2003-4-8-333.asp#Lu

Dissecting C. albicans growth pathways

Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans . Uhl MA, Biery M, Craig N, Johnson AD. EMBO J 2003, 22:2668-2678.

For the Faculty of 1000 evaluation of this article please see: http://genomebiology.com/reports/F1000/gb-2003-4-8-333.asp#Uhl

Knockout rats

Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, Wang YR, Hu R, Lopez-Guajardo CC, Brose HL, Porter KI, et al. Nat Biotechnol 2003, 21:645-651.

For the Faculty of 1000 evaluation of this article please see: http://genomebiology.com/reports/F1000/gb-2003-4-8-333.asp#Zan

ENU mutagenesis and humoral immunity

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Jun JE, Wilson LE, Nelms KA, Goodnow CC and colleagues. Immunity 2003, 18:751-762.

For the Faculty of 1000 evaluation of this article please see: http://genomebiology.com/reports/F1000/gb-2003-4-8-333.asp#Jun