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Table 3 Significantly enriched classes arising both in genes upregulated in A549 xenograft tumors over cell lines and in genes upregulated in U118 tumors over cell cultures (p < 0.05 in both sets)

From: Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice

Category Term Gene count in A549 set of 134 Gene count in U118 set of 112 Gene count in entire set of 5,682 p-value A549 set p-value U118 set
GO term annotation (0.58 terms expected, found 2)
Biological process Cell adhesion 14 9 233 0.001092 0.039587
Molecular function Metal ion binding activity 16 16 411 0.031462 0.006317
MeSH term association (2.2 terms expected, found 42)
Anatomy Basement membrane 9 5 96 3.94E-04 4.04E-02
Anatomy Endothelium, vascular 29 26 829 1.67E-02 9.33E-03
Anatomy Epithelium 22 15 451 7.63E-04 3.04E-02
Anatomy Fibroblasts 40 35 1215 1.25E-02 8.92E-03
Anatomy Microfilaments 7 6 124 2.66E-02 3.51E-02
Anatomy Stem cells 23 20 665 3.69E-02 3.42E-02
Biological sciences Cell adhesion 26 21 697 1.09E-02 2.96E-02
Biological sciences Cell differentiation 53 46 1780 2.53E-02 1.76E-02
Biological sciences Cell movement 29 23 792 9.13E-03 3.36E-02
Biological sciences Gene expression regulation, neoplastic 54 37 1301 3.92E-06 8.56E-03
Biological sciences Neutrophil infiltration 3 3 34 4.51E-02 2.86E-02
Chemicals and drugs Collagen 28 33 516 1.89E-05 4.25E-10
Chemicals and drugs Complementarity determining regions 4 4 32 6.37E-03 3.36E-03
Chemicals and drugs Cytokines 28 26 808 2.10E-02 6.70E-03
Chemicals and drugs DNA, neoplasm 27 22 705 6.70E-03 1.81E-02
Chemicals and drugs Extracellular matrix proteins 15 16 217 1.59E-04 4.32E-06
Chemicals and drugs Growth substances 14 16 365 4.77E-02 1.95E-03
Chemicals and drugs Heparitin sulfate 4 4 54 3.77E-02 2.12E-02
Chemicals and drugs Laminin 13 8 184 3.60E-04 2.82E-02
Chemicals and drugs Lymphokines 16 14 349 7.60E-03 8.22E-03
Chemicals and drugs Metalloendopeptidases 11 12 241 2.63E-02 2.62E-03
Chemicals and drugs Osteonectin 3 5 35 4.85E-02 5.51E-04
Chemicals and drugs Proteoglycans 11 15 255 3.75E-02 1.25E-04
Chemicals and drugs Transcription factor, Sp1 11 10 250 3.32E-02 2.49E-02
Diseases Astrocytoma 7 6 129 3.21E-02 4.13E-02
Diseases Melanoma 18 13 362 1.94E-03 2.50E-02
Diseases Neovascularization, pathologic 13 9 223 2.16E-03 3.11E-02
Diseases Precancerous conditions 11 8 137 3.50E-04 5.38E-03
Diseases Pulmonary fibrosis 5 5 46 4.27E-03 1.96E-03
Diseases Scleroderma, systemic 4 6 58 4.71E-02 9.02E-04