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Archived Comments for: Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata

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  1. cdc24 is not a mating-type specific gene

    sophie lemire-brachat, Biozentrum der Univesitaet Basel

    4 March 2003

    The cdc24 gene is surprisingly mentioned as a mating-type specific gene by Wolfe and colleagues (Table 2). Cdc24, a ubiquitous guanine exchange factor for the small Rho GTPase cdc42, has been shown to be essential in many model organisms including S. cerevisiae and mammalian cells. The use of conditional mutants has shown that cdc24 is a key regulator of cell polarity (by directing the actin cytoskeleton). Although it is activated during mating in yeast via the pheromone signaling to induce mating projection formation, cdc24's major function is to regulate cell polarity during normal cell division (budding).

    For reference:

    Gulli MP, Peter M: Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective. Genes Dev 2001, 15:365-379.

    Competing interests

    None declared