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Table 2 Summary of experimental and in silico data on the ORMDL gene family members

From: ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins

Organism Gene name cDNA (bp) Protein (amino acids) Annotation (from RefSeq, GenBank, TAIR, FlyBase, SGD, YPD, PombePD) Chromosomal location Structural domains* Expression pattern Subcellular localization
H. sapiens ORMDL1 1,092 153 LOC51240 [39] 2q32.2 4 TM Ubiquitous in adult and fetal tissues Endoplasmic reticulum
  ORMDL2 934 153 HSPC160[39] 12q13.2 3 TM Ubiquitous in adult and fetal tissues Endoplasmic reticulum
  ORMDL3 869 153 None 17q21.1 4 TM Ubiquitous in adult and fetal tissues Endoplasmic reticulum
  ORMDL1 (pseudogene) None 10p14 - - -  
  ORMDL2 (pseudogene) None 8q22.1 - - -  
M. musculus ORMDL1 1,815 153 None 1 4 TM NT NT
  ORMDL2 1,053 153 0610012C09 gene [12] 10 4 TM NT NT
  ORMDL3 2,024 153 2810011N17 gene [12] 11 4 TM NT NT
T. rubripes ORMDL1 - 153 None   4 TM NT NT
  ORMDL2 - 153 None   4 TM NT NT
  ORMDL3 - 153 None   4 TM NT NT
C. intestinalis ORMDL - 153 None   4 TM NT NT
D. melanogaster ORMDL 388, partial cds 154 CG14577 [3] 3L 78E6 3 TM Ubiquitous at early embryonic stages and in ectodermal derived tissues at later stages NT
A. thaliana ORMDLa 795 157 F6F3.4; At1g01230§ 1 2 TM NT NT
  ORMDLb none 154 MJC20.10; At5g42000 5 4 TM NT NT
S. cerevisiae ORM1 ¥ none 222 ORM1 [40]; G4089; YGR038w VII 4 TM NT NT
  ORM2 # none 216 YLR350w [41]; L8300.1 XII 4 TM NT NT
S. monacensis ORM1 None 222 ORM1 [40]   4 TM NT NT
S. pombe ORM 1167, partial cds 186 SPBC119.09c [42] 2 3 TM NT NT
E. cuniculi ORMDL - 147 ECU11_1150 [43] XI 4 TM NT NT
  1. *Potential transmembrane segments were predicted using the HMMTOP 2.0 program [26]. Experimental data obtained in the present study. Mapping of mouse ORMDL genes was inferred from syntenic regions between human and mouse chromosomes. § GenBank accession no. AF360237. GenBank accession no. NC_003076. ¥The null mutant constructed in the present study is viable; the double null mutant with ORM2 is viable but shows an impaired growth rate; the ORM1 mRNA is more abundant in MATα cells than in MAT a cells, and at 39°C than at 30°C [44]; ORM1 is coregulated with other 117 genes under 26 cell-damaging conditions [45] and is induced during sporulation [46]; Orm1 protein is produced in mid-log cells [47]. #The null mutant constructed in the present study is viable; the double null mutant with YGR038w (ORM1) is viable but shows an impaired growth rate; Orm2 interacts with Slt2p in a systematic two-hybrid assay [21]; ORM2 is coregulated with other 121 genes under 26 cell-damaging conditions [45] and is induced by a 30 min and 90 min treatment with 1 M NaCl [48]. TM, transmembrane segments; NT, not tested.