Alignment of deduced ORMDL amino-acid sequences. Highly conserved positions (≥ 95%) are shown against a black background, whereas those with conservative exchanges are shown against a grey background. Alignment was performed using the CLUSTALW program . Potential transmembrane segments (TM1 to TM4) are marked with bars above the alignment: Upper bars according to HMMTOP  and lower bars following TMAP . Species abbreviations are as follows: Hsap, human; Mmus, mouse; Rnor, rat; Sscr, pig; Btau, cow; Ggal, chicken; Xlae, Xenopus laevis; Stro, Silurana tropicalis; Frub, Takifugu rubripes (pufferfish); Drer, Danio rerio (zebrafish); Cint, Ciona intestinalis; Dmel, Drosophila melanogaster; Atha, Arabidopsis thaliana; Hvul, Hordeum vulgare (barley); Sbic, Sorghum vulgare; Sreb, Stevia rebaudiana; Lesc, Lycopersicon esculentum (tomato); Gmax, Glycine max (soybean); Mtru, Medicago truncatula; Lpen, Lycopersicon pennellii; Zmay, Zea mays (maize); Scer, Saccharomyces cerevisiae; Smon, Saccharomyces monacensis; Spom, Schizosaccharomyces pombe; Ecun, Encephalitozoon cuniculi.