Figure 1From: Organellar proteomics: the prizes and pitfalls of opening the nuclear envelopeSchematic of the nuclear envelope. The outer nuclear membrane (ONM) and inner nuclear membrane (INM) form a double-membrane system that separates nuclear contents from the cytoplasm. Nuclear pore complexes bridge this system and regulate nucleo-cytoplasmic exchange of macromolecules. Further attachments to many other proteins make purification of individual compartments difficult.Back to article page