Figure 4

Comparison of the human PKC gene loci with chromosomal localization of balanced aberrations in tumors using data from the Cancer Genome Anatomy Project [37]. In addition to the chromosomal abnormality data listed to the right of each gene locus structure diagram, information on the tissue expression of the gene (from expressed sequence tag (EST) databases) and on known human mutations [38,39] is given. Several of the PKC loci are noteworthy, as deletions or translocation events in this chromosomal region are described in the breakpoint map of recurrent chromosomal rearrangements in human neoplasia [22,37]. Cytogenetic studies on recurrent balanced chromosomal aberrations in all hematological malignancies and solid tumors published are collected in [37].