Figure 3
From: Reassignment of specificities of two cap methyltransferase domains in the reovirus lambda2 protein
Stereoview of superimposed structures of the MTase 1 domain (ribbon in green, side chains and labels in red) and VP39 (ribbon and labels in blue, side chains in cyan), delineating the proposed binding sites for the guanine moiety and the target ribose 2'-OH. Capped mRNA is shown in orange and the methylated guanine (black label) is sandwiched between Y22 and F180 of VP39. A conformational change of both the protein and the RNA is required for the cluster of conserved aromatic residues of the reovirus MTase to bind the cap structure in a similar manner.