Table 2 Human Na+/HCO3- cotransporter and cotransporter-like genes
From: A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9at 5q31
Gene name (and common aliases) | Longest coding mRNA sequence (in nucleotides) (with GenBank accession number) | Genomic sequence (GenBank accession number) | Chromosomal location | Number of known ESTs* | Tissues/organs/cell types where expression is shown by ESTs nad/or northern blots (order: normal tissues; tumors; fetal tissues) | mRNA isoforms due to alternative splicing and/or alternative polyadenylation | Reference†|
|---|---|---|---|---|---|---|---|
SLC4A4 (SLC4A5, HNBC1) | 7586 nt NM_003759.1 | AC019089.3 | 4q21 | 109 | Kidney, pancreas (northern, ESTs); brain, liver, prostate, colon, stomach, thyroid, spinal cord; fetal lung, fetal testis (ESTs); no tumor ESTs | 6 | [6] |
SLC4A6 (SLC4A7, HNBC2) | 7785 nt AF047033.1 | AC025392.2, AC024936.3 | 3p22 | 34 | Adult heart (northern), skeletal muscle (northern, ESTs); retina, neuronal precursors, neurons, stomach, colon, uterus, testis, brain, trabecular bone; Gessler-Wilms tumor, liposarcoma, HeLa cells; various fetal tissues (ESTs) | 4 | [2] |
SLC4A8 (HNBC3, KIAA0739) | 4079 nt AB018282.1 | AC025097.9, AC027750.3, AC021343.1 | 12q13 | 13 | Brain (northern, ESTs), skeletal muscle, kidney, thyroid, spinal cord, trachea, adrenal gland (northern), testis (ESTs); germ-cell tumors (ESTs); weak expression in many other organs and various fetal tissues (ESTs) | 4 | [9] |
SLC4A9 | > 3258 nt(submission in progress) | AC008438.1 | 5q31 | 11 | Kidney (northern, ESTs); testis (single EST), fetal brain (long-insert cDNA); no tumor ESTs | 14 | This paper |
NBC4 | 6082 nt AF207661 | AC005041, AC006030.2, AC073263 | 2p11.2 | 16 | Brain, heart, liver, lung, placenta, spleen, stomach (northern); colon, kidney, testis (northern, ESTs); pancreas, uterus, germinal center B cells (ESTs); germ-cell tumors, mantle cell lymphoma, adenocarcinoma; weak expression in other organs (northern) and various fetal tissues (ESTs) | ≥ 2 (not enough data) | [10] |
HNBC7 | > 1383 nt (no acc. #) | AC064816.1, AC018411.3, AL139426.2 | 1p32-31 | 10 | Kidney, prostate, multiple sclerosis lesions, frontal cortex (ESTs); no tumor or fetal ESTs | ≥ 3 (not enough data) | This paper (partial sequence: Unigene Hs.211115) |