Skip to main content

Advertisement

Table 2 FGF knockout mice

From: Fibroblast growth factors

Gene Survival of null mutant* Phenotype References
Fgf1 Viable None identified [110]
Fgf2 Viable Mild cardiovascular, skeletal, neuronal [110,111,112,113,114]
Fgf3 Viable Mild inner ear, skeletal (tail) [115]
Fgf4 Lethal, E4-5 Inner cell mass proliferation [116]
Fgf5 Viable Long hair, angora mutation [72]
Fgf6 Viable Subtle, muscle regeneration [117,118,119]
Fgf7 Viable Hair follicle growth, ureteric bud growth [120,121]
Fgf8 Lethal, E7 Gastrulation defect, CNS development, limb development [67,70,122,123]
Fgf9 Lethal, P0 Lung mesenchyme, XY sex reversal [124]; (J.S. Colvin et al., personal communication)
Fgf10 Lethal, P0 Development of multiple organs, including limb, lung, thymus, pituitary [125,126,127]
Fgf12 (Fhf1) Viable Neuromuscular phenotype (J. Schoorlemmer and M. Goldfarb, personal communication)
Fgf14 (Fhf4) Viable Neurological phenotypes (Q. Wang, personal communication)
Fgf15 Lethal, E9.5 Not clear (J.R. McWhirter, personal communication)
Fgf17 Viable Cerebellar development [17]
Fgf18 Lethal, P0 Skeletal development (N. Ohbayashi, Z. Liu, personal communication)
  1. *E, embryonic day; P, postnatal day.