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Table 1 Phyletic distributions of the six families of UNGs

From: The α/β fold uracil DNA glycosylases: a common origin with diverse fates

Species/family

UNG*

AUDG*

MUG

SsUDG* DRUDG*

   

+ UDGX*

 

Bacteria

    

   Escherichia coli

1

 

1 (MUG)

 

   Haemophilus influenzae

1

1

  

   Neisseria meningitidis

1

1

1 (UDGX)

 

   Rickettsia prowazekii

 

1

  

   Campylobacter jejuni

1

1

1 (UDGX)

 

   Helicobacter pylori

1

1

  

   Bacillus subtilis

1

   

   Mycoplasma genitalium

1

   

   Mycoplasma pneumoniae

1

   

   Ureaplasma urealyticum

1

   

   Deinococcus radiodurans

1

1

1 (MUG)

1

   Mycobacterium tuberculosis 1

 

1

  

   Streptomyces coelicolor

1

2

  

   Synechocystis sp.

 

1

  

   Chlamydia trachomatis

1

   

   Chlamydophila pneumoniae 1

    

   Treponema pallidum

 

1

  

   Borrelia burgdorferi

1

1(d)†

  

   Aquifex aeolicus

 

1

  

   Thermotoga maritima

 

1

  

Archaea

    

   Aeropyrum pernix

 

1

  

   Archaeoglobus fulgidus

 

1

  

   Pyrococcus horikoshii

 

1

  

   Methanobacterium

    

thermoautotrophicum

    

   Methanococcus jannaschii

    

Eukaryota

    

   Saccharomyces cerevisiae

1

 

(r)‡

 

   Schizosaccharomyces pombe1

  

1(MUG)

 

   Caenorhabditis elegans

1

   

   Drosophila melanogaster

(?)§

 

1(MUG)

1

   Homo sapiens

1

 

1(MUG)

1

Large DNA viruses

    

   Poxviruses

1

   

   Herpesviruses

1

   

   Bacteriophages SPO1

 

1

  
  1. *The number of detected representatives of each family is indicated for each species. Note that duplication is uncharacteristic of the UNGs. †(d) indicates a possibly disrupted version in which the amino-terminal conserved motifs are not detectable; ‡(r) indicates an apparent recent loss in S. cerevisiae, as the gene is retained in the related yeast Candida albicans; §(?) indicates the unusual lack of a detectable UNG in both the genome and EST sequences.
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Genome Biology

ISSN: 1474-760X

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