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Table 1 Phyletic distributions of the six families of UNGs

From: The α/β fold uracil DNA glycosylases: a common origin with diverse fates

Species/family UNG* AUDG* MUG SsUDG* DRUDG*
    + UDGX*  
Bacteria     
   Escherichia coli 1   1 (MUG)  
   Haemophilus influenzae 1 1   
   Neisseria meningitidis 1 1 1 (UDGX)  
   Rickettsia prowazekii   1   
   Campylobacter jejuni 1 1 1 (UDGX)  
   Helicobacter pylori 1 1   
   Bacillus subtilis 1    
   Mycoplasma genitalium 1    
   Mycoplasma pneumoniae 1    
   Ureaplasma urealyticum 1    
   Deinococcus radiodurans 1 1 1 (MUG) 1
   Mycobacterium tuberculosis 1   1   
   Streptomyces coelicolor 1 2   
   Synechocystis sp.   1   
   Chlamydia trachomatis 1    
   Chlamydophila pneumoniae 1     
   Treponema pallidum   1   
   Borrelia burgdorferi 1 1(d)   
   Aquifex aeolicus   1   
   Thermotoga maritima   1   
Archaea     
   Aeropyrum pernix   1   
   Archaeoglobus fulgidus   1   
   Pyrococcus horikoshii   1   
   Methanobacterium     
thermoautotrophicum     
   Methanococcus jannaschii     
Eukaryota     
   Saccharomyces cerevisiae 1   (r)  
   Schizosaccharomyces pombe1    1(MUG)  
   Caenorhabditis elegans 1    
   Drosophila melanogaster (?)§   1(MUG) 1
   Homo sapiens 1   1(MUG) 1
Large DNA viruses     
   Poxviruses 1    
   Herpesviruses 1    
   Bacteriophages SPO1   1   
  1. *The number of detected representatives of each family is indicated for each species. Note that duplication is uncharacteristic of the UNGs. (d) indicates a possibly disrupted version in which the amino-terminal conserved motifs are not detectable; (r) indicates an apparent recent loss in S. cerevisiae, as the gene is retained in the related yeast Candida albicans; §(?) indicates the unusual lack of a detectable UNG in both the genome and EST sequences.