- Web report
- Open Access
Topology prediction of membrane proteins
- Todd Richmond
© BioMed Central Ltd 2000
- Received: 18 November 1999
- Published: 17 March 2000
The TopPred 2 server predicts the orientation and location of transmembrane helices in protein sequences.
- Protein Sequence
- Transmembrane Helix
- Transmembrane Region
- Secondary Structure Prediction
- Macintosh Computer
The TopPred 2 server predicts the orientation and location of transmembrane helices in protein sequences. The output of the server includes a GIF graphic of the predicted topology, a summary table of the predicted transmembrane helixes, and then a series of tabular descriptions of the best predicted structures.
Last updated 5 November 1997.
The graphic produced by TopPred 2 is one of the nicer images produced by transmembrane domain prediction servers.
There is no documentation on the website. In order to understand what everything means, you have get the original journal article describing the software.
Instead of just specifying the position of the putative transmembrane domains with numbers, it would be useful to have, in addition, the protein sequence of the predicted helix. This makes it easier for the researcher to annotate that region in the protein sequence.
There are a number of sites that offer transmembrane domain prediction including TMHMM: predication of transmembrane helices in proteins; Tmpred: prediction of transmembrane regions and orientation; HMMTOP: predication of transmembrane helices and topology of proteins; SOSUI: Classification and secondary structure prediction of membrane proteins.