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The first evidence that viruses may subvert signaling pathways from Toll-like receptors within their mammalian hosts has been found.
In nitrate-poor soils, many leguminous plants form nitrogen-fixing symbioses with members of the bacterial family Rhizobiaceae. We selected Rhizobium sp. NGR234 for its exceptionally broad host range, which inclu...
Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another important evolutionary phenomenon involves the evolutionary mob...
Non-long terminal repeat (non-LTR) retrotransposons are eukaryotic mobile genetic elements that transpose by reverse transcription of an RNA intermediate. We have performed a systematic search for sequences ma...
Whole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between distantly related species. Complete genome sequences are ...
Protein Data Bank (PDB) is the recognized public repository for protein structure information.
The first stages in the sea urchin genome project have been reported.
An algorithm has been described that clusters expression data from microarray experiments with respect to subsets of genes and other variables, rather than to all data at once.
A third type III secretion system involved in virulence in Yersinia enterocolitica has been identified.
A new division of the Archaea could be the most ancient living lineage.
We describe a method for printing protein microarrays, and using these microarrays in a comparative fluorescence assay to measure the abundance of many specific proteins in complex solutions. A robotic device ...
A report on the Second International Conference on Bioinformatics of Genome Regulation and Structure, Novosibirsk, 7-11 August, 2000.
The F-box is a protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction. F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (na...
The recent completion and assembly of the first draft of the human genome, which combines samples from several ethnically diverse males and females, provides preliminary data on the extent of human genetic var...
Recent studies have identified silencers as control elements that may interact with enhancers to regulate the expression of imprinted genes.
A report on the Eighth Biannual Xenopus Conference, Estes Park, Colorado, August 16-20, 2000.
The Hox complex is an example of a gene cluster created by tandem duplications. Recent findings suggest the Hox complex may be just part of a larger chromosomal assemblage of homeobox-containing genes that exi...
The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous ...
A report on the 'Host-Pathogen Interactions' minisymposium at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, September 2-6, 2000.
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