© BioMed Central Ltd 2001
Published: 19 March 2001
The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March 15 ScienceXpress, Nakayama et al. describe a role for histone methylation in heterochromatin assembly in the fission yeast Schizosaccharomyces pombe. The Clr4 protein methylated lysine 9 of histone H3 (H3Lys9) preferentially within heterochromatin-associated regions. H3Lys9 methylation led to the recruitment of the chromodomain protein Swi6, a homolog of Drosophila HP1. Both methylation and recruitment were dependent on activity of the histone deacetylase Clr3. Chromatin assembly by Swi6/Clr4 at the mating-type locus results in silencing. Hence, sequential deacetylation and methylation of histone tails leads ultimately to epigenetic inheritance patterns.
- The language of covalent histone modifications.
- ScienceXpress, [http://www.sciencexpress.org]
- Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly, [http://www.sciencemag.org/cgi/content/abstract/1060118v1]
- The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast.
- The chromodomain protein Swi6: a key component at fission yeast centromeres.