%PDF-1.3
%
1 0 obj
<>
endobj
2 0 obj
<>stream
sPLINK,PLINK,Federated learning,Genome-wide association studies,GWAS,Meta-analysis,Privacy
Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
application/pdf
10.1186/s13059-021-02562-1
Genome Biology
Genome Biology, 2022, doi:10.1186/s13059-021-02562-1
sPLINK
PLINK
Federated learning
Genome-wide association studies
GWAS
Meta-analysis
Privacy
sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
Reza Nasirigerdeh
Reihaneh Torkzadehmahani
Julian Matschinske
Tobias Frisch
Markus List
Julian Späth
Stefan Weiss
Uwe Völker
Esa Pitkänen
Dominik Heider
Nina Kerstin Wenke
Georgios Kaissis
Daniel Rueckert
Tim Kacprowski
Jan Baumbach
2022-02-01T07:54:40+01:00
2022-02-01T07:54:40+01:00
2022-01-29T00:13:58+08:00
LaTeX with hyperref package
uuid:5b5275c5-2f13-47c4-a7a2-8e7a00d00a58
uuid:7b3be8b9-029a-4f78-8738-c4294dde4ce1
default
1
converted
uuid:5b5275c5-2f13-47c4-a7a2-8e7a00d00a58
converted to PDF/A-2b
pdfToolbox
2022-02-01T05:45:30+08:00
2
B
Reza Nasirigerdeh
http://orcid.org/0000-0002-2283-5792
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
editorInfo
Bag EditorInformation
external
Editor information: contains the name of each editor and his/her ORCID identifier.
seriesEditorInfo
Bag SeriesEditorInformation
external
Series editor information: contains the name of each series editor and his/her ORCID identifier.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
EditorInformation
http://springernature.com/ns/xmpExtensions/2.0/editorInfo/
editor
Specifies the types of editor information: name and ORCID of an editor.
name
Text
Gives the name of an editor.
orcid
URI
Gives the ORCID of an editor.
SeriesEditorInformation
http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/
seriesEditor
Specifies the types of series editor information: name and ORCID of a series editor.
name
Text
Gives the name of a series editor.
orcid
URI
Gives the ORCID of a series editor.
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
internal
A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.
DerivedFrom
ResourceRef
Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.
http://ns.adobe.com/xap/1.0/sType/Part#
stPart
Part
http://ns.adobe.com/xap/1.0/t/pg/
xmpTPg
XMP Paged-Text
internal
A structure containing the characteristics of a font used in a document
Fonts
Bag Font
internal
XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).
PlateNames
Seq Text
A structure containing the characteristics of a font used in a document.
http://ns.adobe.com/xap/1.0/sType/Font#
stFnt
Font
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
endstream
endobj
3 0 obj
<>
endobj
5 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[167.85 694.038 251.886 702.762]>>
endobj
7 0 obj
<>
endobj
9 0 obj
<>/ExtGState<>/ProcSet[/PDF/Text/ImageC/ImageB/ImageI]/Font<>/XObject<>/Properties<>>>/Annots[30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R]/CropBox[0 0 595 794]/Parent 44 0 R/Rotate 0/MediaBox[0 0 595 794]/TrimBox[0 0 595 794]>>
endobj
45 0 obj
<>
endobj
46 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[247.833 685.038 327.747 694.068]>>
endobj
48 0 obj
<>
endobj
30 0 obj
<>/Rect[119.556 286.356 126.453 294.774]>>
endobj
50 0 obj
<>
endobj
52 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[425.664 631.038 477.804 639.762]>>
endobj
24 0 obj
<>
endobj
31 0 obj
<>/Rect[150.174 286.356 157.071 294.774]>>
endobj
55 0 obj
<>
endobj
56 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[130.995 623.325 180.228 630.762]>>
endobj
25 0 obj
<>
endobj
32 0 obj
<>/Rect[345.24 272.253 352.137 280.68]>>
endobj
62 0 obj
<>
endobj
63 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[201.753 568.038 301.134 576.762]>>
endobj
12 0 obj
[/ICCBased 65 0 R]
endobj
33 0 obj
<>/Rect[402.804 272.253 409.701 280.68]>>
endobj
66 0 obj
<>
endobj
67 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[423.126 487.038 475.266 495.762]>>
endobj
34 0 obj
<>/Rect[468.288 272.253 475.185 280.68]>>
endobj
68 0 obj
<>
endobj
70 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[130.995 479.325 180.228 486.762]>>
endobj
35 0 obj
<>/Rect[119.556 244.056 126.453 252.483]>>
endobj
72 0 obj
<>
endobj
74 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[201.753 424.038 301.134 432.762]>>
endobj
75 0 obj
<>stream
HRMo0WLҒUiKRTCIW{vI-!~glVUo{~i[:c_RE;<
t/k_`u-;Jѥmr)2ڍ1X+O[sc5GY 1EޝaB^#7^FW1Lж5rrH\58G8Y|/mYԦϻO Yj
endstream
endobj
36 0 obj
<>/Rect[119.556 173.577 126.453 181.995]>>
endobj
76 0 obj
<>
endobj
78 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[190.494 388.038 323.931 396.762]>>
endobj
26 0 obj
<>
endobj
37 0 obj
<>/Rect[333.747 145.38 345.549 153.798]>>
endobj
84 0 obj
<>
endobj
85 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[164.529 378.912 279.777 388.068]>>
endobj
18 0 obj
<>
endobj
38 0 obj
<>/Rect[348.066 145.38 359.868 153.798]>>
endobj
90 0 obj
<>
endobj
92 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[243.126 369.912 325.263 378.762]>>
endobj
20 0 obj
<>
endobj
39 0 obj
<>/Rect[329.049 117.183 340.851 125.61]>>
endobj
97 0 obj
<>
endobj
98 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[335.79 262.038 459.363 270.762]>>
endobj
95 0 obj
<>
endobj
40 0 obj
<>/Rect[154.503 103.089 166.305 111.507]>>
endobj
101 0 obj
<>
endobj
81 0 obj
<>
endobj
41 0 obj
<>/Rect[267.336 103.089 279.138 111.507]>>
endobj
102 0 obj
<>
endobj
103 0 obj
<>stream
HdU{Taw$gg}Ep@"a-o,HW^jP
h5b&o{zQӓ{}we,e˲~|M9VK91)ceˏ$,{I,kc!9ؑHٿ
/3fF|SomڦxMtԸ44]lFI㝜 Nׄħ278:ii@j'>I5>U951\v|Q2q8I(f:d921.,a3f&Hΰ3ۂL>q k8hax"mj\ϐ*kP)>Rd).ZͰʶ:g=:u۾]ҳ.3d`R9X#HYHcRo$$pA4)zYWpQy6%DE,/6ES* FAox#6\;yTWkqG滨Hd'ES=.EʖL,䣳x`2#Y?vX-eI
e+MَvqoFqyV0WׯzܬzڈXSYGpuH]f"OnCEEe3+]RG툊/6`]LkU/zt
EĊ(.\/xs`) {x<