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For researchers interested in tumor suppressors, and in particular the p53 protein, this is a useful website; it includes a p53 database, an APC database and a p53 mutation-analysis database
Y.F. Leung's Functional Genomics website is a portal of up-to-date annotated links to databases, software, analysis materials and protocols for functional genomics, microarrays, bioinformatics, proteomics and ...
An expression study of prospective bacterial drug-transporter genes has extended the range of substrates known to be transported and has identified an ABC-family drug transporter in Gram-negative bacteria
A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001.
Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously a...
The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as si...
Recent work has identified the elusive male (pollen) determinant that underlies self-incompatibility in Brassica (cabbage). The key pollen factor, recognized by the stigma of an incompatible plant, is a small cys...
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in var...
Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteri...
A genome-wide scan has revealed multiple conserved groups of neuropeptide genes in the nematode Caenorhabditis elegans
A novel protein-based approach has been developed to import a cell-permeable form of the site-specific recombinase Cre into undifferentiated and terminally differentiated mammalian cells
Dorsoventral patterning in Drosophila oogenesis reveals new links between Ras1 and genes involved in signaling and cytoskeletal organization
The Expression Profiler is an ensemble of web-based computational resources (still under development) for clustering gene-expression data with different algorithms and distance measures, obtaining graphical di...
A report on the 15th Annual Center for Advanced Biotechnology and Medicine Symposium on structural genomics in pharmaceutical design, Princeton, USA, 24-25 October 2001.
Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these ...
A response to Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions by AJ Enright, CA Ouzounis. Genome Biology 2000, 2:research0034.1-0034.7
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