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SMART compares query sequences with its databases of domain sequences and multiple alignments while concurrently identifying compositionally biased regions such as signal peptide, transmembrane and coiled-coil...
The PROCRUSTES server provides a method for determining protein-coding sequences in genomic DNA.
This simple but incredibly useful tool for molecular biologists allows the user to select one or more restriction endonuclease enzymes and determine which of the enzyme buffers provided by New England Biolabs,...
The particular interest of David Ussery and his group is in creating 'structural atlases' of genomes from a detailed analysis of variations in DNA structure.
UniGene, a gene indexing database, is at present the most substantial repository of transcript information from human, rat, mouse and zebrafish.
For those experienced in statistical genetics and genetic mapping this is an excellent resource.
This is a great site for calcium-binding protein enthusiasts.
For those interested in DT40, a chick pre-B-cell line proving increasingly popular for use in gene targeting projects, this is a very useful site.
Detailed descriptions of the design and information content of EBI's database ArrayExpress, which is currently under development but aims to be a public repository of gene expression data, are the main feature...
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
The TopPred 2 server predicts the orientation and location of transmembrane helices in protein sequences.
The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegansand humans.
The GENSCAN program is designed to predict complete gene structures, including exons, introns, promoter and polyadenylation signals, in genomic sequences.
Data are collected from Nature, Science, Cell, and Nature Cell Biologyto form a database and resource for the signaling pathways of human cells.
DIP is intended to help those studying protein-protein interactions, signaling pathways, multiple interactions and complex systems.
The signaling pathway database is an integrated database that links signal transduction systems to genetic information.
A wealth of resources related to the genetics and biology of the mouse can be accessed via this site.
Publicly available nucleotide sequences, along with their associated annotations are available here.
The Genome Database is the official central repository for mapping data from the International Human Genome Initiative.
This online version of a US Department of Energy publication provides detailed background information about the human genome project.
This online publication deals with the ethical, social and legal issues raised by genetic mapping and research.
The primary resource for the zebrafish community is a vast site, and is also a jumping-off point to other relatively large zebrafish websites.
The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.
Valuable information on the use of ribozymes as tools for the analysis of gene function can be found here.
A great site for anyone interested in breast cancer or mammary gland development - beginners and experienced researchers alike.
A new, free-access part of Science's main website, devoted to career advice for junior scientists.
This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules.
The HLA informatics group homepage contains a collection of resources vital to anyone interested in the complex field of HLA alleles.
The first publication of the genomic sequence of an entire human chromosome.
Positive and negative selection for unlinked transposition has been used to generate a large collection of Arabidopsis transposon lines.
A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
The largest contiguous stretch of DNA yet sequenced in Drosophila suggests that fruit-flies have only half as many genes as Caenorhabditis elegans.
The patterns of nucleotide polymorphism in human mitochondrial sequences rock the belief that mitochondria do not recombine.
Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by ...
A novel baculovirus misexpression system is shown to be functional in insect and vertebrate embryos.
Bioinformatic analysis has been used to identify gene-fusion events in complete genomes and thus infer protein interactions on the basis of sequence analysis alone.
Microarray DNA chip technology has been used for the first time to demonstrate the feasibility of cancer classification on the basis of gene-expression profile analysis.
The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.
A genetic screen has identified genes controlling axonal dendrite development.
Can the selection by aminoacyl-tRNA synthetases for the correct tRNA substrate happen during binding? The results of equilibrium experiments suggest that it can.
An analysis of the set of all motifs and repeats found in all protein sequences.
Protein virulence factors can be secreted from bacterial cells using the machinery used to assemble the flagellum.
Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host de...
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