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Ring-type polymerases consist of a DNA polymerase, a ring-shaped sliding clamp protein and a clamp-loading complex. Sliding clamp proteins are found in all organisms and are called proliferating cell nuclear a...
The mechanism by which the plant reserves some cells as pluripotent stem cells while partitioning others into differentiated leaf tissue is fundamental to plant development. New work in Arabidopsis elucidates the...
DNA microarrays are being used to comprehensively examine gene expression networks during the plant defense response that is triggered when a plant encounters a pathogen or an elicitor molecule. In addition to...
To assess how automatic function assignment will contribute to genome annotation in the next five years, we have performed an analysis of 31 available genome sequences. An emerging pattern is that function can...
The Ensembl software automatically produces and archives annotation of the draft human genome sequence.
Three major defense signaling molecules have been shown to trigger partly overlapping gene expression profiles in Arabidopsis.
A report on the 52nd Harden Conference on 'Signaling in Plants', Wye College, Kent, UK, 18-22 September 2000.
The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more importan...
Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P450 genes (also called CYP) are found in the ge...
Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its appl...
Inversions and translocations distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosom...
A report on the 'cDNA arrays/DNA diagnostics' session at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, 2-6 September, 2000.
A report on the 'RNA processsing' and 'Nuclear Import and Export' minisymposia at the first meeting of the European Life Scientist Organization (ELSO), Geneva, 2-6 September, 2000.
A report on the first annual Genomic Arabidopsis Resource Network (GARNet) meeting, York, UK, 2-3 October, 2000.
From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecu...
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