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  1. SAGE is a genome-wide method for obtaining gene expression profiles. It generates tags of 10 nucleotides in length, which are assumed to determine the corresponding gene transcript. In practice however, this i...

    Authors: Jacques Colinge and Georg Feger
    Citation: Genome Biology 2001 2:preprint0002.1
  2. Classic methods of identifying genes involved in neural function include the laborious process of behavioral screening of mutagenized flies and then rescreening candidate lines for pleiotropic effects due to d...

    Authors: Karen L Posey, Leslie B Jones, Rosalinda Cerda, Monica Bajaj, Thao Huynh, Paul E Hardin and Susan H Hardin
    Citation: Genome Biology 2001 2:research0008.1
  3. The recent draft assembly of the human genome provides a unified basis for describing genomic structure and function. The draft is sufficiently accurate to provide useful annotation, enabling direct observatio...

    Authors: Fred A Wright, William J Lemon, Wei D Zhao, Russell Sears, Degen Zhuo, Jian-Ping Wang, Hee-Yung Yang, Troy Baer, Don Stredney, Joe Spitzner, Al Stutz, Ralf Krahe and Bo Yuan
    Citation: Genome Biology 2001 2:preprint0001.1
  4. What is the minimum number of genes or functions necessary to support cellular life? The concept of a 'minimal genome' has become popular, but is it a useful concept, and if so, what might a minimal genome enc...

    Authors: Scott N Peterson and Claire M Fraser
    Citation: Genome Biology 2001 2:comment2002.1
  5. Large-scale expression profiling has revealed distinct clusters of circadian clock-regulated genes and identified a phase-specific cis-regulatory element.

    Authors: Thomas Eulgem
    Citation: Genome Biology 2001 2:reports0005
  6. A comparative study based on four fully sequenced eukaryotic genomes has revealed profound differences in the sets of transcription factors used by plants, fungi and animals.

    Authors: Thomas Eulgem
    Citation: Genome Biology 2001 2:reports0004
  7. A report on the British Society for Immunology Annual Congress, Harrogate, UK, 5-8 December 2000.

    Authors: Rachel L Allen
    Citation: Genome Biology 2001 2:reports4004.1
  8. A report on the 'Critical Assessment of Microarray Data Analysis' (CAMDA 2000) meeting, Durham, North Carolina, USA, December 18-19,2000.

    Authors: James N Siedow
    Citation: Genome Biology 2001 2:reports4003.1
  9. A report on the talks presented at the Cold Spring Harbor 2000 Meeting on Arabidopsis Genomics, New York, 7-10 December, 2000.

    Authors: Pablo D Rabinowicz and Mary E Byrne
    Citation: Genome Biology 2001 2:reports4002.1
  10. Uridine diphosphate (UDP) glycosyltransferases (UGTs) mediate the transfer of glycosyl residues from activated nucleotide sugars to acceptor molecules (aglycones), thus regulating properties of the acceptors s...

    Authors: Joe Ross, Yi Li, Eng-Kiat Lim and Dianna J Bowles
    Citation: Genome Biology 2001 2:reviews3004.1
  11. Chloride-conducting ion channels of the ClC family are emerging as critical contributors to a host of biological processes. These polytopic membrane proteins form aqueous pathways through which anions are sele...

    Authors: Joe Mindell and Merritt Maduke
    Citation: Genome Biology 2001 2:reviews3003.1
  12. With the recent flood of genomic data many researchers have seen their work become more and more quantitative in nature, and found choice of the appropriate statistical analyses is not only essential but also ...

    Authors: I King Jordan
    Citation: Genome Biology 2001 2:reports2002
  13. The Spt4, Spt5, and Spt6 proteins are conserved eukaryotic transcription-elongation factors. Recent studies have provided the first evidence that they are generally required in multicellular eukaryotes, includ...

    Authors: Fred Winston
    Citation: Genome Biology 2001 2:reviews1006.1
  14. Ever since DNA microarrays were first applied to the quantitation of RNA levels, there has been considerable interest in generating a protein homolog that can be used to assay cellular protein expression. A re...

    Authors: Ian M Tomlinson and Lucy J Holt
    Citation: Genome Biology 2001 2:reviews1004.1
  15. Expression arrays have been used to detect mRNAs regulated during sporulation in two strains of Saccharomyces cerevisiae.

    Authors: Rachel Brem
    Citation: Genome Biology 2001 2:reports0003
  16. Caenorhabditis elegans populations in which each gene on chromosome I is blocked in turn by RNAi have been grown and phenotypically screened.

    Authors: Rachel Brem
    Citation: Genome Biology 2001 2:reports0002
  17. Programmed DNA-reorganization and DNA-elimination events take place frequently during cellular differentiation. An extreme form of such processes, involving DNA reorganization, DNA elimination and DNA fragment...

    Authors: Franziska Jönsson, Günther Steinbrück and Hans J Lipps
    Citation: Genome Biology 2001 2:research0005.1
  18. We have developed and tested a method for printing protein microarrays and using these microarrays in a comparative fluorescence assay to measure the abundance of many specific proteins in complex solutions. A...

    Authors: Brian B Haab, Maitreya J Dunham and Patrick O Brown
    Citation: Genome Biology 2001 2:research0004.1

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