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  1. The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define...

    Authors: Charles Brenner

    Citation: Genome Biology 2000 1:reviews103.1

    Content type: Minireview

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  2. The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusion...

    Authors: Claire E Walczak

    Citation: Genome Biology 2000 1:reviews101.1

    Content type: Minireview

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  3. Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-lik...

    Authors: Irina Smirnova, Alexander Poltorak, Edward KL Chan, Colleen McBride and Bruce Beutler

    Citation: Genome Biology 2000 1:research002.1

    Content type: Research

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  4. The use of cDNA microarrays for the study and mapping of gene amplifications and deletions on a whole-genome scale provides a comparison of DNA copy numbers in normal and tumor cells at unprecedented resolution.

    Authors: Aude Fahrer

    Citation: Genome Biology 2000 1:reports011

    Content type: Paper report

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  5. This simple but incredibly useful tool for molecular biologists allows the user to select one or more restriction endonuclease enzymes and determine which of the enzyme buffers provided by New England Biolabs,...

    Authors: Todd Richmond

    Citation: Genome Biology 2000 1:reports232

    Content type: Web report

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  6. The particular interest of David Ussery and his group is in creating 'structural atlases' of genomes from a detailed analysis of variations in DNA structure.

    Authors: Shuba Gopal

    Citation: Genome Biology 2000 1:reports231

    Content type: Web report

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  7. UniGene, a gene indexing database, is at present the most substantial repository of transcript information from human, rat, mouse and zebrafish.

    Authors: Colin Semple

    Citation: Genome Biology 2000 1:reports230

    Content type: Web report

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  8. For those interested in DT40, a chick pre-B-cell line proving increasingly popular for use in gene targeting projects, this is a very useful site.

    Authors: Julie Curran

    Citation: Genome Biology 2000 1:reports227

    Content type: Web report

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  9. Detailed descriptions of the design and information content of EBI's database ArrayExpress, which is currently under development but aims to be a public repository of gene expression data, are the main feature...

    Authors: Paul Kellam

    Citation: Genome Biology 2000 1:reports226

    Content type: Web report

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  10. Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.

    Authors: Mar Albà

    Citation: Genome Biology 2000 1:reports225

    Content type: Web report

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  11. The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegansand humans.

    Authors: Todd Richmond

    Citation: Genome Biology 2000 1:reports223

    Content type: Web report

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  12. Data are collected from Nature, Science, Cell, and Nature Cell Biologyto form a database and resource for the signaling pathways of human cells.

    Authors: Iain Gilfillan

    Citation: Genome Biology 2000 1:reports221

    Content type: Web report

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  13. This online version of a US Department of Energy publication provides detailed background information about the human genome project.

    Authors: Basil Safwat

    Citation: Genome Biology 2000 1:reports215

    Content type: Web report

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  14. This site has a collection of features dealing with different areas of genetic research, and is an interesting and useful piece of 'popular science'.

    Authors: Basil Safwat

    Citation: Genome Biology 2000 1:reports213

    Content type: Web report

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  15. The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.

    Authors: Aengus Stewart

    Citation: Genome Biology 2000 1:reports210

    Content type: Web report

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  16. This comprehensive online biology reference book consists of lists of terms covering an extensive range of biological topics, and is aimed primarily at graduate students.

    Authors: Ines Chyla

    Citation: Genome Biology 2000 1:reports207

    Content type: Web report

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  17. A great site for anyone interested in breast cancer or mammary gland development - beginners and experienced researchers alike.

    Authors: Bryony Wiseman

    Citation: Genome Biology 2000 1:reports206

    Content type: Web report

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  18. SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC mole...

    Authors: Christopher J Thorpe

    Citation: Genome Biology 2000 1:reports203

    Content type: Web report

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  19. The first publication of the genomic sequence of an entire human chromosome.

    Authors: Jonathan B Weitzman

    Citation: Genome Biology 2000 1:reports019

    Content type: Paper report

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  20. Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by ...

    Authors: William Deakin

    Citation: Genome Biology 2000 1:reports013

    Content type: Paper report

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  21. Bioinformatic analysis has been used to identify gene-fusion events in complete genomes and thus infer protein interactions on the basis of sequence analysis alone.

    Authors: Paul Kellam

    Citation: Genome Biology 2000 1:reports009

    Content type: Paper report

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  22. The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.

    Authors: William Deakin

    Citation: Genome Biology 2000 1:reports007

    Content type: Paper report

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  23. Protein virulence factors can be secreted from bacterial cells using the machinery used to assemble the flagellum.

    Authors: William Deakin

    Citation: Genome Biology 2000 1:reports003

    Content type: Paper report

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  24. Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.

    Authors: Jonathan B Weitzman

    Citation: Genome Biology 2000 1:reports002

    Content type: Paper report

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  25. YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host de...

    Authors: Jonathan B Weitzman

    Citation: Genome Biology 2000 1:reports001

    Content type: Paper report

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