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A large family of G-protein-coupled receptors, with sequence homology to the oncoprotein MAS1, has been shown to be specifically expressed in nociceptive sensory neurons.
Predicted extracellular proteins of Bacillus subtilis have been compared with the experimental identification of the extracellular proteome by two-dimensional gel electrophoresis, peptide sequencing and mass spec...
Transcriptional profiling of 60 human cancer lines has been used to assess chemosensitivity to 232 chemical compounds.
Genetic evidence supports the recognition and conservation management of African forest and savannah elephants as two distinct species.
Systematic examination of the gene encoding CYP2B6, a human cytochrome P450, has characterized genetic polymorphisms that might account for its variability in expression and function between individuals.
Granzymes, a family of serine proteases, are expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells, components of the immune system that protect higher organisms against viral infectio...
All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeri...
Gene-expression profiling has yielded important information about simple systems, but complex tissues have not yet been widely profiled. Four recent studies of mammalian skeletal muscles have added to the cata...
Symbioses between unicellular and multicellular organisms have contributed significantly to the evolution of life on Earth. As exemplified by several studies of bacterium-insect symbioses, modern genomic techn...
A report on the International conference on Halophilic Microorganisms, Sevilla, Spain, 23-27 September 2001.
A report on the symposium 'Mycobacteria - new developments' at the 149th meeting of Society for General Microbiology, University of East Anglia, Norwich, UK, 10-13 September 2001.
Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is necessary for the creation of large-scale gene expression ...
Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative rates test in an attempt to assess the rate constancy...
The biomedical community is rapidly developing new methods of data analysis for microarray experiments, with the goal of establishing new standards to objectively process the massive datasets produced from fun...
A response to Evidence for symmetric chromosomal inversions around the replication origin in bacteria by JA Eisen, JF Heidelberg, O White, SL Salzberg. Genome Biology 2000, 1:research0011.1-0011.9.
Protein-protein interactions have decisive roles in almost all aspects of the structural and functional organization of cells. But in spite of the increasing amount of complete genome sequence data, the abilit...
A report on the ESF/LESC Exploratory Workshop 'Understanding Chromosome Behaviour: Prospects for Constructing Chromosome-Based Vectors for Gene Therapy', Elmau, Germany, 27-30 September 2001.
A report on the 2001 Eukaryotic DNA Replication meeting, Cold Spring Harbor Laboratory, New York, 5-9 September 2001.
Very small genomes have evolved repeatedly in eubacterial lineages that have adopted obligate associations with eukaryotic hosts. Complete genome sequences have revealed that small genomes retain very differen...
Sequestration of transcription factors in the membrane is emerging as an important mechanism for the regulation of gene expression. A handful of membrane-spanning transcription factors has been previously iden...
Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by expe...
The BMERC website provides a platform for searching DNA, RNA and protein sequence databases and performing bioinformatic analyses.
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