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TBASE is a database of information on all transgenic mice and targeted mutations, with particular emphasis on knockouts.
A multiple copy gene family on the human Y chromosome has been shown to be transcribed but not translated.
A novel protein upregulated in certain cancers has been identified and characterized using an integrated proteomics, genomics, bioinformatics and standard molecular biology approach.
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. They have proved particularly effective in multidisciplinary genetic studies. Widespread use of RI stra...
The primary sequence of Xist seems not to be important for Xist to function in X-chromosome inactivation.
Apoptosis is a physiological cell death process important for development, homeostasis and the immune defence of multicellular animals. The key effectors of apoptosis are caspases, cysteine proteases that clea...
In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute...
A report on Novartis Foundation Symposium 244 "The Genetics and Biology of Sex Determination", London, UK, 1-3 May 2001.
The evolutionary history of eukaryotic proteins involves rapid sequence divergence, addition and deletion of domains, and fusion and fission of genes. Although the protein repertoires of distantly related spec...
Two recent reports describe mRNA and protein expression patterns in the bacterium Caulobacter crescentus. The combined use of DNA microarray and proteomic analyses provides a powerful new perspective for unraveli...
Microarrays of mouse genes are now available from several sources, and they have so far given new insights into gene expression in embryonic development, regions of the brain and during apoptosis. Microarray d...
A report on the second European conference on zebrafish genetics and development. University College, London, 19-22 April 2001.
A report from HGM2001, the sixth annual International Human Genome Meeting organized by The Human Genome Organisation (HUGO), Edinburgh, UK, 19-22 April 2001.
The ExPASy proteomics server is a dedicated site for the analysis of protein sequences, protein structures and two-dimensional polyacrylamide gel electrophoresis.
A novel in silico method based on comparative and physicochemical considerations can help to predict the impact of amino-acid replacement on protein structure and function.
An in silico approach has been used to sort the effects on protein structure or function of amino-acid substitutions at conserved compared to non-conserved sites.
The SRY gene has been shown to be a direct transcriptional target of the WT1 transcription factor.
MacroH2A1 and macroH2A2 are two different histone loci with probable common genetic ancestry.
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