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The effects of launch vibrations and microgravity on the cytoskeletal organization of a Jurkat leukemic cell line flown in space have been identified using a microarray approach.
A new computational method for whole-genome analysis by in silico restriction mapping has been developed and has been evaluated by comparison with experimental restriction analysis of tumor DNA.
A critical evaluation of the quality of different versions of the draft human genome sequence has revealed discrepancies between experimental mapping results and data available online.
A human sperm-specific protein has been isolated that may prove useful in the development of a contraceptive vaccine.
The broad-ranging Asthma and Allergy Gene Database covers many aspects of asthma and allergy genetics, including linkage data, gene expression data and gene therapy trials.
HOMOPHILA is a searchable database of human disease genes, obtained from the Online Mendelian Inheritance in Man database, that have significant homology at the protein level to genes contained in FlyBase, the...
The Prostate Expression Database (PEDB) is an on-site database of expressed sequences from both normal and diseased prostate tissues, with an integrated suite of bioinformatics tools for analyzing gene express...
A report on the Euroconference on Fungal Virulence Factors and Disease: 'Human Fungal Pathogens', Seefeld, Austria, 8-13 September 2001.
A report on the 674th meeting of the Biochemical Society, Dublin, Ireland, 11-12 July 2001.
"From winter, plague and pestilence, good Lord, deliver us."
Variation in a region of chromosome 4 may contribute to the probability of living to age 100.
Having a working draft of the human genome sequence is proving invaluable to mouse genetic and genomic studies, providing a useful stepping-stone towards the finished sequence of the mouse genome.
Epithelial tissues house γδ T cells, which are important for the mucosal immune system and may be involved in controlling malignancies, infections and inflammation. Whole-genome gene-expression analysis provid...
The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have...
The number of genes predicted for the Caenorhabditis elegans genome is remarkably high: approximately 20,000, if both protein-coding and RNA-coding genes are counted. This article discusses possible explanations ...
A report on the Ninth International Gap Junction Conference, Honolulu, USA, 4-9 August 2001.
A report on the 18th Congress of the European Society for Evolutionary Biology (ESEB), Aarhus, Denmark, 20-25 August, 2001.
Searching for similarities between biological sequences is the principal means by which bioinformatics contributes to our understanding of biology. Of the various informatics tools developed to accomplish this...
A report on the FASEB meeting on Chromatin and Transcription, Snowmass, USA, 7-12 July 2001.
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