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The mechanism by which Bacillus anthracis initiates anthrax in humans involves key protein-protein interactions, the site for which have now been mapped
Understanding how Bacillus anthracis initiates anthrax in humans
Understanding the secretion of an enterotoxin by enterotoxigenic Escherichia coli strains paves the way to the development of new drugs
Sequencing Thermoanaerobacter tengcongensis reveals clues as to how this thermophile manages to live an extreme lifestyle
The specificity of tissue transcriptional activities may be understood via high-throughput gene-expression profiling of a significant fraction of the human and mouse transcriptomes
The evolutionary origin of double fertilization and the resultant endosperm tissue in flowering plants remains a puzzle, despite over a century of research. The recent resurgence of approaches to evolutionary ...
The destiny of a cell - whether it undergoes division, differentiation or death - results from an intricate balance of many regulators, including oncoproteins, tumor-suppressor proteins and cell-cycle-associat...
The publication of the Fugu rubripes draft genome sequence will take this fish from culinary delicacy to potent tool in deciphering the mysteries of human genome function.
A report on the British Society for Cell Biology (BSCB) meeting on 'Cell Biology and Neurobiology: A Meeting for Martin Raff', London, UK, 3-5 July 2002.
A report on the Genome-Based Pathogen Biology meeting, Hinxton, UK, 7-10 July 2002.
Comprehensive microarrays covering large numbers of the predicted expressed transcripts for some invertebrates and vertebrates have been available for some time. Despite predictions that this technology will t...
An excellent candidate for the master sex-determining gene on the Y chromosome of the medaka fish is not related to the mammalian SRY gene
A report on the First International Conference on Legume Genomics and Genetics: Translation to Crop Improvement, Minneapolis-St. Paul, USA, 2-6 June 2002.
Cardio-vascular diseases are the first cause of death worldwide, particularly in the developed countries; the identification of genes specifically expressed in the cardiac muscle is thus of major biomedical in...
In the pharmaceutical industry and in academia substantial efforts are made to make the best use of the promising microarray technology. The data generated by microarrays are more complex than most other biolo...
The complete genome sequence of the antibiotic-producing bacterium Streptomyces coelicolor should aid the genetic engineering of new anti-bacterial compounds
The distribution of orthologous genes within the major histocompatibility complex paralogous regions of amphioxus and humans supports the idea of genome-wide duplication events in vertebrate evolution
The study of galactose metabolism in Trypanosoma brucei reveals possible new drug targets
Clostridium perfringens secretes a cysteine protease in a VirR/VirS-dependent manner
Determination of the complete genome sequence of the methanogen Methanosarcina acetivorans reveals unusual metabolic versatility
Disparity between primate phylogenetic trees that are based on mitochondrial versus nuclear DNA is likely to be due to differences between lineages in nucleotide substitution bias in the mitochondrial genomes
DNA shuffling has proven to be a powerful technique for the directed evolution of proteins. A mix of theoretical and applied research has now provided insights into how recombination can be guided to more effi...
Examination of cyclic gene expression in the suprachiasmatic nuclei (SCN) and liver suggests tissue-specific circadian cycles corresponding to organ-specific physiological functions
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