Fig. 5

Pan-cancer characterisation of individual G0 stress response programmes. a-e Comparison of correlation coefficients between stress response programme scores and a mean expression of CDK4 and CDK6, b mean expression of curated contact inhibition genes, c a transcriptional MAPK Pathway Activity Score (MPAS), d mean expression of curated serum starvation genes and e CDKN1A expression (encoding for p21), across TCGA cancers. The correlations expected to be strongest (either negative or positive) are denoted by an asterisk. The generic G0 arrest score refers to scores calculated using the original list of 139 genes differentially expressed across all 5 forms of G0 arrest. f Comparison of stress response programme scores measured in cancer cell lines before (grey) and after (red) palbociclib treatment across three validation studies. Datasets used for validation are denoted by their corresponding GEO series accession number. g Predicted stress response diversity in samples with high levels of G0 arrest across individual cancer types. The same colour legend as in a is applied. Grey bars represent the proportion of samples for which the G0 arrest inducer could not be estimated