Fig. 2
From: Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer
Pan-cancer evaluation of proliferative heterogeneity and linked tumour hallmarks. a PHATE plot illustrating the wide spectrum of proliferative to slow cycling/arrested states across 8005 primary tumour samples from TCGA. Each sample is coloured according to the relative G0 arrest level. b Variation in tumour G0 arrest levels across different cancer tissues. c Correlation between mean G0 arrest capacity and stem cell division estimates for various tissue types. d Correlating tumour G0 arrest scores with cancer cell stemness (Stemness Index), telomerase activity (EXTEND score), p21 activity (CDKN1A) and the expression of several commonly used proliferation markers. The Pearson correlation coefficient is displayed. RC replication complex. e Consistently higher levels of G0 arrest are detected in samples with functional p53. f Lower G0 arrest scores are observed in tumours with one or two whole-genome duplication events. Wilcoxon rank-sum test p-values are displayed in boxplots, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001