Fig. 4

Categorization of human genes with no named orthologs in VGNC. (Left) Pie chart showing proportion of named human protein-coding genes with and without approved orthologs in VGNC, as of January 2022 (n = 19,220). (Right) Pie chart categorizing reasons that no VGNC orthologs were approved for some human genes, as of January 2022 (n = 1367). Complex gene family members = 759 genes; lineage-specific duplication = 234 genes; Nomenclature issues = 99 genes; Human readthrough annotations = 76 genes (*all 76 genes have since been approved in VGNC); Lacking HCOP support = 54 genes; Closely related human genes = 34 genes; Annotation issues in VGNC species = 19 genes; Not in current human annotation set = 14 genes, Other = 78 genes. See article text for further explanation of each category and Additional file 3: Table S3 for full list of genes, which also indicates genes that have subsequently been approved in VGNC via manual curation