Fig. 1

The SeATAC model and tasks for performance evaluation. a A full V-plot has a width of 640-bp genomic region and a height of 640 bp of fragment sizes (left panel). An array of 5 × 10 pixels is aggregated together and become a single larger pixel, resulting in a 128 × 64 pixels image (right panel). The heatmap color indicates the normalized read density. b SeATAC models the ATAC-seq V-plot using a conditional variational autoencoder (CVAE) framework. c Six separate tasks for evaluating the performance of detecting chromatin accessibility changes. MACS2 was excluded from tasks #2 and #3