Fig. 7

Atypical POE module 3, the module whose internal connectivity increased with age. a Pairwise between-CpG correlation of constituent CpGs of atypical POE module 3 across different age groups. Horizontal line: the mean of the methylation correlation across all age groups. b Three subclusters identified within atypical POE module 3 based on longitudinal trajectory of module connectivity; each line connects the methylation correlation value of a pair of POE-CpGs in different age groups; the color of the line corresponds to the rank of the standard deviation based on the connectivity of POE-CpG pairs across different age groups. c Methylation connectivity of POE-CpG pairs belonging to the “sharply increasing cluster” in each age group. Orange nodes represent POE-CpGs, the size of the orange nodes is scaled by degree centrality (the IDs of the top 5 hub CpGs are shown), the width of the edges is scaled by pairwise correlation in samples from each age group. Only edges connecting CpGs pairs with an absolute value of correlation larger than 0.4 are shown