Fig. 4
From: Modeling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data
voomByGroup captures both biological and technical variation. a Summary of the simulation design with unequal numbers of cells per sample, with colors denoting the different groups in the dataset. In the scenario with technical variation only (unequal library sizes) across groups, mean-variance trends estimated by voomByGroup are plotted in panel (b), with group-wise common BCVs displayed in the top-right corner. Based on DE analysis results, FDRs across methods for different comparisons, denoted by distinct colors, are summarized in panel (c) at an FDR cut-off of 0.05