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Fig. 8 | Genome Biology

Fig. 8

From: m6A readers ECT2/ECT3/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis

Fig. 8

A working model for the regulatory roles of m6A readers CPSF30-L and ECT2/ECT3/ECT4. In the nucleus, CPSF30-L binds m6A-modified transcripts and regulates its poly(A) site choice; in the cytoplasm, m6A readers ECT2, ECT3, and ECT4 interact each other, where ECT2/ECT3/ECT4 bind m6A-modified transcripts tightly and recruit the poly(A) binding proteins through the direct interaction between ECT2 and PAB2/PAB4, thereby preventing deadenylation and stabilizing their targeted mRNA. In ABA response, ECT2/ECT3/ECT4 redundantly maintain mRNA stability of ABA response-related genes (e.g., DWA1, DWA2, SDIRIP1, and CPN20), thereby repressing the accumulation of ABI5 and regulating ABA-mediated seed germination and post-germination growth

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Genome Biology

ISSN: 1474-760X

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