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Fig. 2 | Genome Biology

Fig. 2

From: Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota

Fig. 2

Short-term caloric restriction changes the gut microbiota composition. A Pairwise orthogonal projection to latent structure-discriminant analysis (OPLS-DA) analysis of fecal samples (n = 9–10 per group). B,C Principal coordinate analysis (PCoA) of the Bray–Curtis and weighted_unifrac distances of feces from AL or CR mice at 7 weeks and 11 weeks (n = 9–10 per group). D–G Indexes of observed_otus, evenness, faith_pd, Shannon of feces from AL or CR mice at 7 weeks and 11 weeks (n = 9–10 per group). H Comparison of phylum-level proportional abundance of feces from AL and CR mice at 7 weeks and 11 weeks (n = 9–10 per group). I Classification model between the AL and CR groups at 11 weeks based on random forests. J Heatmap of 20 OTUs which were highly predictive for the differentiation of the gut microbiota between CR and AL groups (n = 9–10 per group). K Eleven identified OTUs selected from total 20 OTUs by STAMP. Significance was calculated using the Kruskal–Wallis test (alpha diversity) and permutational multivariate analysis of variance test (beta diversity). ∗ p < 0.05, ∗  ∗ p < 0.01, ∗  ∗  ∗ p < 0.001, ∗  ∗  ∗  ∗ p < 0.0001

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