Fig. 3From: Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cellsGuide RNA exchange can be avoided by using different Cas species for KI and base editing. Graphical display of gRNA exchange between the Cas9 nuclease and the Cas9 base editor that can be prevented by applying a Cas12a nuclease in combination with a Cas9 base editorBack to article page