Fig. 2

Ability of SNV and species-FEAST to recapitulate true contributions in simulations. Estimated known and unknown source proportions for infant microbiomes simulated with in silico mixtures of real maternal fecal microbiomes under different scenarios: either a small number of contributing sources (≤ 5) or large number of sources (6–11), and a high transmission rate of species or low transmission rate. The transmission rate is the probability of an infant being colonized by a given species, simulated using a beta distribution centered on the relative abundance of species in sources (see the “Methods” section). Twenty-three infants were simulated with five or fewer sources and 19 infants were simulated with a large number of sources (Table S1). The black line indicates the ground truth for proportions. For each simulated infant, there are 11 points plotted, whereby 10 correspond to known sources (some of which have zero contribution), and one corresponds to an unknown source which is indicated by hollow circles in the plot