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Fig. 5 | Genome Biology

Fig. 5

From: A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

Fig. 5

Interpretation for DSB formation model in the context of 3D chromatin structure. a DSB-surrounding space, rather than the cleavage site itself, may develop the DSB through its FaCIN with key chromatin interactions spatially organized like a bottleneck. b Example on Hi-C contact map to explain the model in a. The neck interaction connects a DSB site and its non-DSB neck neighbor. The well-established DSB signals of CTCF binding and accessible chromatin, however, do not show up at the cleavage site, but occur at its neck neighbor

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Genome Biology

ISSN: 1474-760X

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