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Fig. 3 | Genome Biology

Fig. 3

From: A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

Fig. 3

Characterization of neck interactions in the context of chromatin structure. a Ratio for neck interactions being loop is marked with blue dot, while the ratio for random interactions (10 repeats) is displayed with box. Neck interactions are significantly enriched in loop anchors (p < 0.001, hypergeometric test). b E-P loops show no enrichment of neck interactions. c Example for the FaCIN of DSB site at chr1: 7,885,000–7,889,999 reflected on Hi-C contact map. TADs are separated by black dashed lines. d Ratio for neck interactions that entirely locate in a TAD is marked with red dot, while for random interactions (10 repeats) this ratio is marked with box. Neck interactions are more likely to locate in a TAD than random interactions (p < 0.001, hypergeometric test)

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Genome Biology

ISSN: 1474-760X

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