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Fig. 2 | Genome Biology

Fig. 2

From: A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

Fig. 2

The bottleneck pattern of FaCIN. a Top: An overall schematic of FaCIN in the context of 3D chromatin structure. Tangled lines represent the intricate folding of chromatin. Bottom: Chromatin is binned with size of 5 kb and interacting bin pairs are abstracted into circles circled by ellipse. Each genome bin (ellipse) corresponds to a node (edge) on the right for a graphic form of FaCIN. Blue edge (ellipse) linking nodes a and b represents a neck interaction between the genome regions related to nodes a and b. Purple edges represent other interactions in FaCIN. b FaCINs with different neck interaction number and their corresponding reflection on Hi-C contact maps. Squares on Hi-C contact map are colored according to their role within a FaCIN. c Top-2 motifs that are enriched in FaCINs

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Genome Biology

ISSN: 1474-760X

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