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Fig. 2 | Genome Biology

Fig. 2

From: The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles

Fig. 2

Distributional shift and quantile normalization. A Experimental signal measuring H3K4me3 in BE2C cells from an unnormalized training set experiment (gray), an unnormalized test set experiment in SJSA1 cells (green), the test set signal after quantile normalization (blue), the test set signal after single-end reprocessing (red), and the test set signal after single-end reprocessing and quantile normalization (purple). B Distributions of signal values within peaks in chr16/17 for each reprocessed assay across the unnormalized training set (gray), the unnormalized test set (green), the single-end reprocessed test set (red), and the single-end reprocessed and quantile-normalized test set (purple). The KS statistics between the training set distribution and the test set distributions are shown in the legends and the CDFs are summarized using 25 dots for visualization purposes. C An example locus that exhibits a DNase peak in both the training and test sets. D A re-scoring of the challenge participants against single-end reprocessed and quantile-normalized test set signal

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