Fig. 7

NSD2 EK-mediated epigenetic changes correlate with 3D genome changes. a Bar plots showing distribution of annotated ChiP-seq peaks for each epigenetic mark for NSD2-Low and NSD2-High in each cell line. b Correlation boxplots of H3K36me2 ChIP-seq and cscore compartment switches. c Association barplots showing fraction of differential H3K36me2 chip-seq peaks (decreased, increased, and no change) at cscore compartment switches (AB, BA, and stable). d KEGG 2021 pathway enrichment analysis of genes upregulated from NSD2-Low to NSD2-High that overlap with B to A compartment switches and increased H3K36me2 peaks from all three cell lines. e IGV genome browser tracks showing an example of concordant changes in A/B compartments, H3K36me2, and gene expression from NSD2 Low to NSD2 High at the NCAM1 gene locus in all three cell lines