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Fig. 5 | Genome Biology

Fig. 5

From: NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

Fig. 5

NSD2 knockdown has minimal impact on intra-TAD activity. a Volcano plots demonstrating differential intra-TAD activity from NSD2 Low to NSD2 High per cell line (abs(L2FC) > 0.25, FDR < .01). b Venn diagram showing overlap of differential TADs between three B-ALL cell lines, decreased and increased (left and right respectively). c Correlation boxplots showing gene expression and chromatin accessibility changes within differential TADs. d Association barplots showing fraction of compartment switches and shifts (compaction, stable B, stable A, and decompaction) at intra-TAD activity changes (increased, decreased, or stable). e Example of a TAD activity alteration using Hi-C contact matrices for RS4;11 at the FGF5 locus showing an increase in intra-TAD activity (NSD2-Low, NSD2-High, and L2FC(High/Low) from left to right)

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